Separation of N′-nitrosonornicotine isomers and enantiomers by supercritical fluid chromatography tandem mass spectrometry

Deng, Huimin; Wang, Ying; Wang, Jinbang; Liu, Shanshan; Ji, Yuan; Fan, Ziyan; Li, Zhonghao; Yang, Fei; Bian, Zhaoyang; Tang, Gangling

doi:10.1016/j.chroma.2021.461971

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Chromatography1

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2022

2023

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Cited by 5 publications

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“…A supercritical fluid extraction-SFC-triple quadrupole MS (SFE-SFC-QQQMS) was developed for the determination of chiral metholaxin, benzoyl, and dimethylamine in hemp seeds with the LODs of 0.04–0.41 μg kg –1 on a commercial ChromegaChiral Column (Merck Life Science) . In addition, chiral pesticides of mefentrifluconazole, N ′-nitrosonicotine, and fluindapyr were successfully separated and determined by SFC on commercial vancomycin (VancoShell), Chiralpak (Illkirch Cedex), and Chiralcel (Daiecl) columns. − SFC is an ideal technology for the separation and purification of chiral drugs owing to its short separation time and high sample throughput. Hayes et al built a microscale SFC-based purification platform via the alteration of fluid channel and introduction of gas–liquid separators for the discovery and analysis of pharmaceuticals on ChiralPak Column (Westchester).…”

Section: Chromatographymentioning

confidence: 99%