Separation of OH-containing compounds from the essential oil mixture via a one-pot synthesis of carbamates, antimicrobial evaluation and dynamic 1H NMR study of their derivatives

Abstract

A series of various carbamate derivatives were synthesized using essential oils of various plants and cyclohexyl or phenyl isocyanate under solvent-free conditions. Carvacrol, Thymol and Eugenol were chosen for synthesis that exist in Satureja bachtiarica Bunge, Satureja hortensis L., Trachyspermum ammi and Caryophyllus aromaticus, respectively. Essential oils after extraction and identification by GC-MS, were used as raw material for synthesis of carbamate derivatives. Antimicrobial activity of synthesized compounds was examined against four Gram-negative and Gram-positive bacteria as well as three fungal strains. Good inhibitory activities were observed with synthesized compounds. Also 1H NMR dynamic of synthetic carbamates were investigated for this compounds.