Separation of particles in non-Newtonian fluids flowing in T-shaped microchannels

D’Avino, Gaetano; Hulsen, Martien A.; Maffettone, Pier Luca

doi:10.1186/s40323-015-0033-9

Cited by 8 publications

(3 citation statements)

References 55 publications

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“…In nonNewtonian viscoelastic liquids, indeed, particle dynamics through the bifurcation is affected by the development of normal stresses in the suspending liquid that induce particle cross-streamline migration [15,16].…”

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confidence: 99%

Numerical design of a T-shaped microfluidic device for deformability-based separation of elastic capsules and soft beads

2017

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Document VersionAccepted manuscript including changes made at the peer-review stage Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. (2017). Numerical design of a T-shaped microfluidic device for deformability-based separation of elastic capsules and soft beads. Physical Review E, 96(5), [053103]. DOI: 10.1103/PhysRevE.96.053103 Link to publication Citation for published version (APA): General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. We propose a square cross section microfluidic channel with an orthogonal side branch (asymmetric T-shaped bifurcation) for the separation of elastic capsules and soft beads suspended in a Newtonian liquid on the basis of their mechanical properties.The design is performed through 3D direct numerical simulations.When suspended objects start near the inflow channel centerline and the carrier fluid is equally partitioned between the two outflow branches, particle separation can be achieved based on their deformability, with the stiffer ones going 'straight' and the softer ones being deviated to the 'side' branch. The effects of the geometrical and physical parameters of the system on the phenomenon are investigated.Since cell deformability can be significantly modified by pathology, we give a proof of concept on the possibility of separating diseased cells from healthy ones, thus leading to illness diagnosis.

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confidence: 99%

Numerical design of a T-shaped microfluidic device for deformability-based separation of elastic capsules and soft beads

2017

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“…Recently, interest in the flow of suspensions through channel bifurcations has been growing in microfluidics and biology due to the problem of particle separation [8]. Partitioning of erythrocytes, leukocytes, and platelets at vascular junctions plays an important role in determining microvascular hematocrits and has important physiological implications.…”

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confidence: 99%

Flows of Dense Suspensions of Polymer Particles through Oblique Bifurcating Channels: Two Continua Approach

Shelukhin

Антонов

2022

Polymers

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A two-velocity mathematical model is proposed for dense suspension flows through channel bifurcations. Equations agree with thermodynamic laws and they are suitable for both heavy and light particles. The pulsatile mode of injection of particles is considered. In the 2D-case, we address the issue of partitioning particles and study how a loss of particles into the side branch depends on the bifurcation angle. A qualitative agreement with experiment data are established. We capture the Zweifach–Fung effect. We treat polymer particles as a phase enjoying the rheology of the Bingham viscoplastic material. We prove that the polymer particle distribution between two branches correlates with the averaged-in-time Bingham number in these branches.

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“…Grid-based methods are able to capture accurately the dynamics of particles in viscoelastic media modelled by several constitutive equations -e.g Oldroyd-B, Maxwell, Giesekus, PTT, FENE-like etc. -and have been successfully applied to study the rotation of a sphere in a viscoelastic liquid subjected to shear a) Electronic mail: A.Vazquez-Quesada@swansea.ac.uk b) Electronic mail: M.Ellero@swansea.ac.uk flow 21 , confinement effects on viscoelasticity-induced cross-stream particle migration 22,23 , particle-interaction in a shear flow 19,24 and recently particle separation and sorting in microfludics devices 25 . Despite their great accuracy, these techniques are to date limited to small systems, i.e.…”

Section: Introductionmentioning

confidence: 99%

SPH modeling and simulation of spherical particles interacting in a viscoelastic matrix

Vázquez-Quesada

Ellero

2017

Physics of Fluids

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In this work, we extend the three-dimensional Smoothed Particle Hydrodynamics (SPH) non-colloidal particulate model previously developed for Newtonian suspending media in Vázquez-Quesada and Ellero [“Rheology and microstructure of non-colloidal suspensions under shear studied with smoothed particle hydrodynamics,” J. Non-Newtonian Fluid Mech. 233, 37–47 (2016)] to viscoelastic matrices. For the solvent medium, the coarse-grained SPH viscoelastic formulation proposed in Vázquez-Quesada, Ellero, and Español [“Smoothed particle hydrodynamic model for viscoelastic fluids with thermal fluctuations,” Phys. Rev. E 79, 056707 (2009)] is adopted. The property of this particular set of equations is that they are entirely derived within the general equation for non-equilibrium reversible-irreversible coupling formalism and therefore enjoy automatically thermodynamic consistency. The viscoelastic model is derived through a physical specification of a conformation-tensor-dependent entropy function for the fluid particles. In the simple case of suspended Hookean dumbbells, this delivers a specific SPH discretization of the Oldroyd-B constitutive equation. We validate the suspended particle model by studying the dynamics of single and mutually interacting “noncolloidal” rigid spheres under shear flow and in the presence of confinement. Numerical results agree well with available numerical and experimental data. It is straightforward to extend the particulate model to Brownian conditions and to more complex viscoelastic solvents.

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Separation of particles in non-Newtonian fluids flowing in T-shaped microchannels

Cited by 8 publications

References 55 publications

Numerical design of a T-shaped microfluidic device for deformability-based separation of elastic capsules and soft beads

Numerical design of a T-shaped microfluidic device for deformability-based separation of elastic capsules and soft beads

Flows of Dense Suspensions of Polymer Particles through Oblique Bifurcating Channels: Two Continua Approach

SPH modeling and simulation of spherical particles interacting in a viscoelastic matrix

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