Background: The aim of this paper is to combine different types of information necessary for a first rather qualitative assessment of deep geothermal reservoirs in the region of Luxembourg. Within the geological framework, the study area encompasses Luxembourg and the surrounding areas of Belgium, Germany, and France. On the one hand, the focus is laid on low-enthalpy hydrothermal reservoirs in Mesozoic aquifers in the Trier-Luxembourg Embayment. On the other hand, petrothermal reservoirs in the Devonian basement of the Ardennes and Eifel regions are considered for exploitation by Enhanced/Engineered Geothermal Systems (EGS). Methods: For geothermal exploration and exploitation purposes, geological, thermal, hydrogeological and structural data are necessary. Results: Among the Mesozoic aquifers, the Buntsandstein aquifer characterized by temperatures of up to 50°C is a suitable hydrothermal reservoir that could be exploited by means of heat pumps or provide direct heat for various applications. The most promising area is the zone of the SE-Luxembourg Graben. The aquifer is the warmest underneath the upper Alzette valley and the limestone plateau in Lorraine, where the Buntsandstein aquifer lies below a thick Mesozoic cover. At the base of an inferred Rotliegend graben in the same area, temperatures of up to 75°C are expected. However, geological and hydraulic conditions are uncertain. In the Lower Devonian basement, thick sandstone-/quartzite-rich formations with temperatures >90°C are expected at depths >3.5 km and likely offer the possibility of direct heat use. The setting of the Südeifel (South Eifel) region, including the Müllerthal region near Echternach, as a tectonically active zone may offer the possibility of deep hydrothermal reservoirs in the fractured Lower Devonian basement. Based on recent data on the structure of the Trier-Luxembourg Basin, the new concept presents the Müllerthal-Südeifel Depression as a Cenozoic tectonic structure that is still mobile and relevant for geothermal exploration. Conslusion: Beyond direct use of geothermal heat, the expected modest temperatures at 5 km depth (about 120°C) and increased permeability by EGS in the quartzite-rich Lochkovian could prospectively enable combined geothermal heat production and power generation in Luxembourg and the western realm of the Eifel region.