Separation of sugars by continuous annular chromatography

Howard, A. J.; Carta, Giorgio; Byers, Charles H.

doi:10.1021/ie00082a020

Cited by 67 publications

(48 citation statements)

References 7 publications

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“…Several authors used calcium resins to fractionate mixtures of fructose, glucose and sucrose [14][15][16]. However, potassium (K + ) and sodium (Na + ) cations are the most recommended ions for the separation of these sugar mixtures due to their advantage in providing higher kinetic rates of adsorption [17,18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of adsorption equilibrium of fructose, glucose and sucrose on potassium gel-type and macroporous sodium ion-exchange resins

Nobre

Santos

Dominguez

et al. 2009

Analytica Chimica Acta

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a b s t r a c tAdsorption equilibrium of fructose, glucose and sucrose was evaluated on sulfonated poly(styrene-codivinylbenzene) cation-exchange resins. Two types of resins were used: potassium (K + ) gel-type and sodium (Na + ) macroporous resins. Influence of the cation and effect of the resin structure on adsorption were studied. The adsorption isotherms were determined by the static method in batch mode for monocomponent and multi-component sugar mixtures, at 25 and 40• C, in a range of concentrations between 5 and 250 g L −1 . All adsorption isotherms were fitted by a linear model in this range of concentrations. Sugars were adsorbed in both resins by the following order: fructose > glucose > sucrose. Sucrose was more adsorbed in the Na + macroporous resin, glucose was identically adsorbed, and fructose was more adsorbed in the K + gel-type resin. Data obtained from the adsorption of multi-component mixtures as compared to the mono-component ones showed a competitive effect on the adsorption at 25• C, and a synergetic effect at 40• C. The temperature increase conducted to a decrease on the adsorption capacity for mono-component sugar mixtures, and to an increase for the multi-component mixtures. Based on the selectivity results, K + gel-type resin seems to be the best choice for the separation of fructose, glucose and sucrose, at 25• C.

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Section: Introductionmentioning

confidence: 99%

Comparison of adsorption equilibrium of fructose, glucose and sucrose on potassium gel-type and macroporous sodium ion-exchange resins

Nobre

Santos

Dominguez

et al. 2009

Analytica Chimica Acta

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“…In the former case, several groups have reported that the equilibrium isotherms of these sugars on ion-exchange resins were linear (Ching and Ruthven, 1985;Balannec and Hotier, 1994). Howard et al (1988) reported it to be linear up to at least 200 g/L. Similarly, Barker et al (1983) found linear isotherms in the study of the separation of high molecular-weight dextranes on silicagel, using size exclusion chromatography.…”

Section: Introductionmentioning

confidence: 85%

Effect of the flow rates in linear, ideal, simulated moving‐bed chromatography

1997

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“…Continuous annular chromatography (CAC) has been the subject of several recent experimental studies (120,121), models (122,123) and a brief review (124). The equipment is very similar to the CRAE (Figure 7).…”

Section: • Novel Methods In Traditional Geometriesmentioning

confidence: 99%

Modeling and Applications of Downstream Processing

Hamel

Hunter

1990

ACS Symposium Series

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Downstream processing is playing an increasingly important role in the biochemical industry, especially since the advent of recombinant DNA technology. The use of recombinant DNA technology not only enables improvements in the production efficiency of therapeutic and industrial proteins, but it also permits the modification and improvement of protein structure and thus function.However, the commercial application of such technology was initially accompanied by concerns over product safety.Quality criteria have been made especially stringent for products derived from genetically-modified microorganisms. The establishment of strict quality guidelines was the result of early concern about the oncogenic potential related to products contaminated by DNA sequences of the host mammalian cells (1). The quest for high quality has created a growing need for high-resolution techniques at the process scale as well as for novel strategies for the isolation and purification of bioproducts. Since the typical environment for producing biologicals is a complex one and quality criteria need to be strict, primary recovery techniques are typically implemented in a purification scheme prior to (or in conjunction with) high-resolution techniques. The most sophisticated and useful schemes take advantage of both the different physical and chemical properties of the components in complex mixtures and of the interactive nature of the downstream processing techniques (see Figure 1).

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Separation of sugars by continuous annular chromatography

Cited by 67 publications

References 7 publications

Comparison of adsorption equilibrium of fructose, glucose and sucrose on potassium gel-type and macroporous sodium ion-exchange resins

Comparison of adsorption equilibrium of fructose, glucose and sucrose on potassium gel-type and macroporous sodium ion-exchange resins

Effect of the flow rates in linear, ideal, simulated moving‐bed chromatography

Modeling and Applications of Downstream Processing

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