A 2D mathematical model was developed in this study to simulate acetone separation from water by using a microstripper device. Model validation was implemented through a comparison of simulation results of acetone removal from water and experimental data for dry nitrogen over a wide range of carrier gas and liquid velocities. A comparison of experimental data and simulation results illustrated reasonable agreement. The results indicate that increasing the liquid velocity reduces the acetone removal rate because increasing liquid velocity results in a decrease in the residence time of liquid in the liquid channel, whereas there is an enhancement in acetone removal with increasing carrier gas velocity. A sharp decrease in acetone concentration in the liquid channel was observed.