Seprafilm® interposition for preventing adhesion formation after tenolysis

Karakurum, Gunhan; Buyukbebeci, Orhan; Kalender, Murat; Güleç, Akif

doi:10.1016/s0022-4804(03)00204-x

Cited by 48 publications

(32 citation statements)

References 14 publications

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“…To prevent the injured surfaces in contact with each other, a surgical barrier strategy has been developed in which a mechanical barrier separates the surgically traumatized tissue surfaces during the immediate postoperative interval. A variety of materials has been used as barrier materials to reduce postoperative adhesions in randomized clinical trials at specific sites after surgery [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of resorbable barrier for preventing surgical adhesions

Zhang

Tian

Cui

2005

Current Applied Physics

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Section: Introductionmentioning

confidence: 99%

Evaluation of resorbable barrier for preventing surgical adhesions

Zhang

Tian

Cui

2005

Current Applied Physics

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“…Both study groups showed better ranges of motion and reduced histopathological adhesions compared with the control groups. A similar study was performed to evaluate the efficiency of Seprafilm in prevention of adhesion formation after tendolysis on chicken flexor tendons [38]. With Seprafilm interposition, a higher average gliding excursion value was found.…”

Section: Seprafilm®mentioning

confidence: 99%

Biodegradable Films in Trauma and Orthopedic Surgery

Jürgens

Schulz²,

Porté³

et al. 2006

Eur J Trauma

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Resorbable materials have gained a considerable position in the daily routine of all surgical disciplines. Natural products like catgut and collagen have been used historically. Since the development of synthetical macromolecules more than 40 years ago, the range of indications for the use of such materials has widened significantly in our daily routine. Suture materials, mesh, tissue pads, clips, screws and anchors are in use. More recent developments in the field of orthopedic and trauma surgery include screw-plate systems, wound dressing materials and films for the prevention of adhesions and ossifications. This appears to be the beginning of an era of new materials as these implants not only fulfil a temporary biomechanical role but in theory also can release a controlled amount of biologically active substances at a set timeframe. Also they are potential carriers for transplants on a cellular level. This aspect will be of importance in the orthopedic field, where resorbable films only play a minor role so far.At the moment there are six resorbable or biodegradable films or foils on the market that are used or can be used in the field of orthopedic and trauma surgery.These are foils and films made of following materials: carboxy-methyl-cellulose and hyaloronic acid (Seprafilm®), oxydized regenerated cellulose (Interceed®), polydioxanon (PDS®) and copolymers of lactid und caprolacton (Topkin®, Oprafol®, Mesofol®).Main indications for their use are wound dressing, especially after split skin graft and thermal wounds, prophylaxis of adhesions and prevention of the formation of synostoses and heterotopic ossifications. The results of clinical trials are promising and the increasing number of publications in the last 5 years in this field is an expression of increasing demand of these materials. However, it could also be an expression of the growing interest in drug delivery techniques as well as in tissue engineering which are possible with these materials.

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“…28 The pulling rate of FDP tendon was 5 mm/min, and the displacement and the load (N) were recorded. The pullout force (N) was defined as the maximum force necessary to pull the tendon out of the tendon sheath.…”

Section: Biomechanical Analysismentioning

confidence: 99%

Preparation and characterization of antiadhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion

Chen¹,

Chen²,

Shalumon³

et al. 2014

IJN

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Peritendinous adhesion is one of the common complications encountered after tendon injury and subsequent surgery, and it can be minimized by introducing a physical barrier between the injured site and the surrounding tissue. An electrospun hyaluronic acid-grafted poly(caprolactone) (PCL-g-HA) nanofibrous membrane (NFM) is proposed as an alternative to current antiadhesion barrier films. HA is covalently grafted to surface-aminolyzed PCL nanofibers, using carbodiimide as the coupling agent. Pristine PCL and PCL-g-HA NFMs were characterized by scanning electron microscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, and mechanical testing. In vitro cell culture with fibroblasts showed that PCL-g-HA NFMs reduced cellular adhesion on the membrane surface while maintaining cell proliferation. Animal experiments using a rabbit flexor digitorum profundus tendon model confirmed the efficacy of PCL-g-HA in reducing peritendinous adhesion, based on gross observation, histology, joint flexion-angle measurements, gliding tests, and biomechanical evaluation.

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Seprafilm® interposition for preventing adhesion formation after tenolysis

Cited by 48 publications

References 14 publications

Evaluation of resorbable barrier for preventing surgical adhesions

Evaluation of resorbable barrier for preventing surgical adhesions

Biodegradable Films in Trauma and Orthopedic Surgery

Preparation and characterization of antiadhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion

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