Sepramesh vs. Dualmesh for abdominal wall hernia repairs in a rabbit model

Young, Ricardo; Gustafson, Robert A.; Dinsmore, Robert C.

doi:10.1016/j.cursur.2003.09.011

Cited by 27 publications

(13 citation statements)

References 3 publications

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“…The defect area after three weeks ranged from 32.1±5.5 to 35.6±3.1 squared centimeters and was similar to other reports that made only the acute full-thickness defect with areas ranging from 35 to 40 squared centimeters 9,10,18,[30][31][32][33][34][35][36][37][38] . The hypothetic advantage of our model was to simulate the surgical findings in the human hernia repair.…”

Section: Discussionsupporting

confidence: 71%

“…In guinea pigs the size was reported as 3x1 cm 26 and in pigs as 10x10 cm 13 , 12x4 cm 12 or 5 cm of diameter 14 . In rabbits the wall defect was referred to sizes of 2x3 cm 27 , 3x3 cm 11,28 , 9x2 cm 18 , 7x3 cm 29 , 5x7 cm [30][31][32] , 7x5 cm 9,33-37 and 5x8 cm 10 . Only one study 38 made reference to the relationship of 2x3 cm wall resection with the percentage of the defect (60-70%) to the total area of the abdominal wall of the mice.…”

Section: Discussionmentioning

confidence: 99%

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Animal model of chronic abdominal hernia in rabbit

Silva

Fagundes

Seidel³

et al. 2009

Acta Cir. Bras.

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Purpose: To create a feasible animal model of hernia that should be reliable to test the different types of mesh and/or surgical technique. Methods: Thirty six male New Zealand albino rabbits were submitted to surgical procedure to provoke a standard hole in the abdominal wall. A metallic frame measuring 3 cm length and 1 cm width was allocated longitudinally on the umbilicus scar and the comprehensive three squared centimeters area was resected. A continuous 4.0 polyamide was performed to closure the subcutaneous and skin. Results: During three weeks a score of signals/symptoms was performed to evaluate the wound and clinical conditions. No death or severe complications occurred. In the 3rd week the hernia ring and visceral adhesions were evaluated. Soft omental adherences were present in the hernial sac in all animals. The area of hernia ring ranged from 32.1±5.5 to 35.6±3.1 squared centimeter and the maximum was 39 cm 2 and the minimum was 30 cm 2 . The model results in protrusion which was similar to a human incisional hernia with hernia sac, visceral adhesions and fibrous healing ring. Conclusion: The model was more reliable to test further techniques or mesh on hernia repair. Key words: Hernia, Ventral. Hernia, Abdominal. Wound Healing. Animal Experimentation. Rabbits. RESUMO Objetivo:Criação de um modelo animal de hérnia que seja confiável para testar as diferentes técnicas e tipos de telas. Métodos: Trinta e seis coelhos foram submetidos a procedimento operatório que provocou uma falha na parede abdominal. Uma moldura metálica com 3 cm de comprimento e 1 cm de largura foi colocada longitudinalmente sobre a cicatriz umbilical e ressecada uma área de 3cm 2 . Uma sutura contínua de poliamida 4.0 fechou a tela subcutânea e pele. Resultados: durante três semanas o escore de sinais e sintomas foi coletado para avaliar as condições clínicas e da ferida operatória. Não ocorreram óbitos ou complicações graves. Na terceira semana o anel herniário e aderências peritoneais foram avaliadas. Aderências frouxas estavam presentes no saco herniário em todos os animais. A área do anel herniário variou de 32.1±5.5 a 35.6±3.1 cm 2 , com um máximo de 39 cm 2 e um mínimo de 30 cm 2 . O modelo resultou numa protrusão de vísceras semelhante ao que ocorre em hérnia incisional de humanos. Conclusão: O modelo é factível para testar técnicas operatórias ou telas na reconstrução de hérnias incisionais.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Animal model of chronic abdominal hernia in rabbit

Silva

Fagundes

Seidel³

et al. 2009

Acta Cir. Bras.

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“…Another possibility is the precoating of PP with extracellular matrix (ECM) components such as collagen. These meshes are available as Sepramesh (Genzyme, Germany) [28]. Precoating with ECM appeared to reduce the incidence of adhesions but increases the infection rate [6,24,25].…”

Section: Discussionmentioning

confidence: 99%

Precoating of alloplastic materials with living human fibroblasts—a feasibility study

Kapischke

Prinz²,

Tepel

et al. 2005

Surg Endosc

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“…In studies comparing HA/CMC-coated PPM with PTFE coated PPM, we see controversial results. In some studies HA/CMC coated PPM is found to be more effective in preventing adhesion formation [21][22][23] whereas in others the opposite occurs [24,25] . ORC, on the other hand is very seldom used in hernia models to prevent adhesion.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Adhesion to Prosthetic Mesh in Incisional Ventral Hernias: Comparison of Different Barriers in an Experimental Model

Dilege¹,

Coşkun²,

Gündüz³

et al. 2006

Eur Surg Res

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Background: The purpose of this study was to compare the intra-abdominal adhesion formation following ventral hernia repair by using oxidized regenerated cellulose (ORC) as a barrier underneath polypropylene mesh (PPM), and sodium hyaluronate/carboxymethylcellulose (HA/CMC)-coated PPM. Methods: A ventral abdominal defect was created in each of 30 male rats which were divided into three groups. In group 1 (control) the defect was repaired with PPM; in group 2 ORC was laid over the viscera and the defect was repaired with PPM, and in group 3 HA/CMC-coated PPM was used for the repairing procedure. On the 28th postoperative day all the rats were sacrificed and adhesions were evaluated by laparoscopic exploration followed by histopathological examination. Results: Animals treated with ORC and PPM, and HA/CMC-coated PPM showed significantly less adhesions than the control group (p = 0.026) and the intra-abdominal adhesions of the rats in these two groups were significantly easier to release than in the control group (p = 0.001). There was no significant difference between the ORC and HA/CMC groups. Conclusions: ORC used together with PPM is as effective as HA/CMC-coated PPM and ORC can be used as an adhesion barrier in intra-abdominal hernia repair.

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Sepramesh vs. Dualmesh for abdominal wall hernia repairs in a rabbit model

Cited by 27 publications

References 3 publications

Animal model of chronic abdominal hernia in rabbit

Animal model of chronic abdominal hernia in rabbit

Precoating of alloplastic materials with living human fibroblasts—a feasibility study

Prevention of Adhesion to Prosthetic Mesh in Incisional Ventral Hernias: Comparison of Different Barriers in an Experimental Model

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