Sepsis, a 2020 review for the internist

Purcarea, Adrian; Sovaila, S.

doi:10.2478/rjim-2020-0012

Cited by 51 publications

(50 citation statements)

References 49 publications

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“…Sepsis is a serious infection response with high morbidity and mortality. Rapid diagnosis and urgent intervention are Evidence-Based Complementary and Alternative Medicine very important to improve the prognosis [14]. Although rapid and accurate analysis of pathogens causing infection remains a major challenge in modern health care, molecular detection has created a new progress in diagnosis of sepsis by improving early intervention performance and reducing mortality [15,16].…”

Section: Discussionmentioning

confidence: 99%

Characterization of lncRNA-Based ceRNA Network and Potential Prognostic Hub Genes for Sepsis

Tong

Yang

Feng

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Sepsis is one of the most common reasons for hospitalization and in-hospital mortality each year. Noncoding RNAs have been reported not only as diagnostic and prognostic indicators but also as therapeutic targets of sepsis. Herein, we used an integrative computational approach to identify miRNA-mediated ceRNA crosstalk between lncRNAs and genes in sepsis based on the “ceRNA hypothesis” and investigated prognostic roles of hub genes in sepsis. Methods. Two good-quality gene expression datasets with more than 10 patient samples, GSE89376 and GSE95233, were employed to obtain differentially expressed lncRNAs (DElncRNAs) and genes (DEGs) in sepsis. The DElncRNA-miRNA-DEG regulatory network was constructed using a combination of DElncRNA-miRNA pairs and miRNA-DEmRNA pairs. The protein-protein interaction (PPI) network was constructed by mapping DEGs into the STRING database to identify hub genes in sepsis. The clinical and prognostic significance of hub genes was validated in 89 patients with post-traumatic sepsis. Results. The integrative computational approach identified 311 DEGs and 19 DElncRNAs between septic patients and healthy volunteers. Results yielded 122 downDElncRNA-miRNA-downDEG networks based on two lncRNAs, HCP5, and HOTAIRM1, and 36 upDElncRNA-miRNA-upDEG network based on BASP1-AS1. The PPI network identified serum/glucocorticoid regulated kinase 1 (SGK1), arrestin beta 1 (ARRB1), and G protein-coupled receptor 183 (GPR183) as located at the core of the network, and three of them were downregulated in sepsis. SGK1, ARRB1, and GPR183 were all involved in lncRNA HCP5-based ceRNA network. The quantitative real-time PCR revealed that the patients with post-traumatic sepsis exhibited reduced relative mRNA levels of SGK1, ARRB1, and GPR183 compared to the patients without sepsis. The nonsurvivor group, according to the 28-day mortality, showed lower relative mRNA levels of SGK1, ARRB1, and GPR183 than the survivor group. We also demonstrated reduced mRNA levels of SGK1, ARRB1, and GPR183 were associated with sepsis-related death after trauma. Conclusion. Our integrative analysis and clinical validation suggest lncRNA HCP5-based ceRNA networks with SGK1, ARRB1, and GPR183 involved were associated with the occurrence and progression of sepsis.

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Section: Discussionmentioning

confidence: 99%

Characterization of lncRNA-Based ceRNA Network and Potential Prognostic Hub Genes for Sepsis

Tong

Yang

Feng

2022

Evidence-Based Complementary and Alternative Medicine

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“…Fever, AMS, and autonomic instability in an elderly patient may be the earliest manifestations of various pathological conditions. In the emergency room setting, elderly patients with multiple comorbidities often present with sepsis, a diagnosis with a mortality rate of approximately 26%, and requiring urgent interventions to improve outcomes [ 18 ]. PHS is another life-threatening medical emergency, yet because of the severe presentation in elderly patients, and the multi-organ damage incurred, it is not uncommon to misdiagnose PHS.…”

Section: Discussionmentioning

confidence: 99%

Parkinsonism-Hyperpyrexia Syndrome: A Case Series and Literature Review

Azar¹,

Jaber²,

Ayyad³

et al. 2022

Cureus

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Parkinsonism-hyperpyrexia syndrome (PHS) is a rare, potentially fatal neurological emergency, that is seen in Parkinson's Disease (PD) patients and mimics neuroleptic malignant syndrome. The most common trigger for PHS is sudden withdrawal of anti-parkinsonian medications, specifically levodopa. However, it can also be due to Deep Brain Stimulation (DBS) device malfunction. In this work, we describe three cases of PHS; the first of which is related to DBS battery depletion, and the remaining two to dopaminergic withdrawal. Additionally, we will include the results of a literature review on PHS, its etiologies, presentation, and management.

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“…At about 3 days after disease, NK cells produce fast reactions to infection tainted cells and other intracellular microorganisms, and they answer cancer development. Invulnerable cells perceive the significant histocompatibility complex (MHC) on tainted cell surfaces, which sets off the development of cytokines, which makes the contaminated cell bite the dust by lysis or apoptosis [7]. NK cells, on the other hand, are unusual in that they can detect and destroy stressed cells without the need of antibodies or MHC, allowing for a much speedier immune response.…”

Section: The Sustainable Development Goals and Sepsismentioning

confidence: 99%

Roles of NK Cells in Sepsis

Baesmat

2022

JAMMR

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Purpose: The body's severe reaction to an infection is known as sepsis. It's a medical emergency that might put your life in jeopardy. Sepsis occurs when an existing infection sets off a chain reaction throughout your body. Sepsis is caused by infect ions that begin in the lungs, urinary tract, skin, or gastrointestinal system. During prolonged sepsis, apoptosis and diminished immunological activities of natural killer (NK) cells contribute to patients' vulnerability to secondary/nosocomial infections and viral reactivation, resulting in worse life quality and long-term death. Methods: The gene expression data were retrieved from Gene Expression Omnibus (GEO) (GSE60424). Fold change and p value analysis, hierarchical clustering, and pathway analysis were performed. Results: In this study, we identified altered genes involved in sepsis in NK cells. Ten genes corresponding 11 probe sets were differentially expressed following the sepsis. We identified a network between these genes and pathways they belong to. Pathway analysis showed that these genes are mostly associated with autoimmune response. Conclusion: DLL1, SERPINA1, IFI44L, XCL1, CD3G, IGHM, PAX8-AS1, PACSIN1, PDE4B and SCML1 genes were found to be associated with sepsis. Almost all these genes are effective in the autoimmune response, especially during the sepsis. Therefore, it is hypothesized that downregulation or upregulation of these genes may affect immune response. And it is predicted that NK cells may be an important factor for autoimmune disease.

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Sepsis, a 2020 review for the internist

Cited by 51 publications

References 49 publications

Characterization of lncRNA-Based ceRNA Network and Potential Prognostic Hub Genes for Sepsis

Characterization of lncRNA-Based ceRNA Network and Potential Prognostic Hub Genes for Sepsis

Parkinsonism-Hyperpyrexia Syndrome: A Case Series and Literature Review

Roles of NK Cells in Sepsis

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