Sepsis and SOFA score: related outcome for critically ill renal patients

Carbonell, Nieves; Blasco, María Luisa; Ferreres, José; Blanquer, José; García-Ramón, R; Mesejo, A.; Miguel, Alfonso

doi:10.5414/cnp62185

Cited by 15 publications

(24 citation statements)

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“…Furthermore, decreased glucose concentration in the blood is a sign of gluconeogenesis disturbances, which usually accompany increased insulin secretion often observed in the case of sepsis (Hirasawa et al 2009). The enhanced TAG level apparent during sepsis is a consequence of lipid metabolism failure (Baue 1991) while kidney dysfunction often results in an increased serum creatinine level (Carbonell et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels

Винокуров

Ostrov

Yurinskaya

et al. 2012

Cell Stress and Chaperones

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It has been previously reported that pretreatment with exogenous heat shock protein 70 (Hsp70) is able to protect cells and animals from the deleterious effects of bacterial lipopolysaccharide (LPS) produced by Gramnegative bacteria. However, the effects of Hsp70 pretreatment on lipoteichoic acid (LTA) challenge resulted from Gram-positive bacteria infection have not been fully elucidated. In this study, we demonstrated that preconditioning with human recombinant Hsp70 ameliorates various manifestations of systematic inflammation, including reactive oxygen species, TNFα, and CD11b/CD18 adhesion receptor expression induction observed in different myeloid cells after LTA addition. Therefore, exogenous Hsp70 may provide a mechanism for controlling excessive inflammatory responses after macrophage activation. Furthermore, in a rat model of LTA-induced sepsis, we demonstrated that prophylactic administration of exogenous human Hsp70 significantly exacerbated numerous homeostatic and hemodynamic disturbances induced by LTA challenge and partially normalized the coagulation system and multiple biochemical blood parameters, including albumin and bilirubin concentrations, which were severely disturbed after LTA injections. Importantly, prophylactic intravenous injection of Hsp70 before LTA challenge significantly reduced mortality rates. Thus, exogenous mammalian Hsp70 may serve as a powerful cellular defense agent against the deleterious effects of bacterial pathogens, such as LTA and LPS. Taken together, our findings reveal novel functions of this protein and establish exogenous Hsp70 as a promising pharmacological agent for the prophylactic treatment of various types of sepsis.

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Section: Discussionmentioning

confidence: 99%

Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels

Винокуров

Ostrov

Yurinskaya

et al. 2012

Cell Stress and Chaperones

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“…In developing the present guideline, PubMed was used to identify papers which compared septic and non-septic AKI. Nine observational studies were identified [78,[98][99][100][101][102][103][104][105]; seven of these studies were prospective, while two were retrospective. One of these studies was a retrospective study by Bagshaw et al which utilized the Australian and New Zealand Intensive Care Society (ANZICS) database [78]; the study featured 14,039 septic AKI patients and 29,356 non-septic AKI patients, a prominently large number of patients compared to other studies.…”

Section: Commentarymentioning

confidence: 99%

“…One of these studies was a retrospective study by Bagshaw et al which utilized the Australian and New Zealand Intensive Care Society (ANZICS) database [78]; the study featured 14,039 septic AKI patients and 29,356 non-septic AKI patients, a prominently large number of patients compared to other studies. Seven studies compared in-hospital mortality [78,[98][99][100][101][102][103], while five studies compared ICU mortality [78,100,101,104,105].…”

Section: Commentarymentioning

confidence: 99%

“…As for AKI diagnostic criteria, six studies used the RI-FLE criteria [78,[99][100][101][102][103]; the remaining three studies [98,104,105] were published before the RIFLE criteria were proposed. Percentages of patients by RIFLE criteria severity were listed in four studies [78,99,100,102]; Risk was the most common level of severity in one study [100], while Injury was the most common in two studies [78,99], and Failure was the most common in one study [102].…”

Section: Commentarymentioning

confidence: 99%

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The Japanese Clinical Practice Guideline for acute kidney injury 2016

et al. 2018

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Acute kidney injury (AKI) is a syndrome which has a broad range of etiologic factors depending on different clinical settings. Because AKI has significant impacts on prognosis in any clinical settings, early detection and intervention are necessary to improve the outcomes of AKI patients. This clinical guideline for AKI was developed by a multidisciplinary approach with nephrology, intensive care medicine, blood purification, and pediatrics. Of note, clinical practice for AKI management which was widely performed in Japan was also evaluated with comprehensive literature search.

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“…Studies have demonstrated the importance of age and male gender, the latter possibly due to preexistent vascular diseases (1,3,4,6,10,13,(20)(21)(22)(23). The delay before ARF onset, Acute Physiology, Age and Chronic Health Evaluation II (APACHE II) score and length of stay in the ICU seem to be important, probably because they are markers of the severity of the patient's condition (24).…”

Section: Introductionmentioning

confidence: 99%

Incidence, risk factors and prognostic factors of acute renal failure in patients admitted to an intensive care unit

Mataloun¹,

Machado²,

Senna³

et al. 2006

Braz J Med Biol Res

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The objective of the present study was to assess the incidence, risk factors and outcome of patients who develop acute renal failure (ARF) in intensive care units. In this prospective observational study, 221 patients with a 48-h minimum stay, 18-year-old minimum age and absence of overt acute or chronic renal failure were included. Exclusion criteria were organ donors and renal transplantation patients. ARF was defined as a creatinine level above 1.5 mg/dL. Statistics were performed using Pearsons' χ 2 test, Student t-test, and Wilcoxon test. Multivariate analysis was run using all variables with P < 0.1 in the univariate analysis. ARF developed in 19.0% of the patients, with 76.19% resulting in death. Main risk factors (univariate analysis) were: higher intra-operative hydration and bleeding, higher death risk by APACHE II score, logist organ dysfunction system on the first day, mechanical ventilation, shock due to systemic inflammatory response syndrome (SIRS)/sepsis, noradrenaline use, and plasma creatinine and urea levels on admission. Heart rate on admission (OR = 1.023 (1.002-1.044)), male gender (OR = 4.275 (1.340-13642)), shock due to SIRS/sepsis (OR = 8.590 (2.710-27.229)), higher intra-operative hydration (OR = 1.002 (1.000-1004)), and plasma urea on admission (OR = 1.012 (0.980-1044)) remained significant (multivariate analysis). The mortality risk factors (univariate analysis) were shock due to SIRS/sepsis, mechanical ventilation, blood stream infection, potassium and bicarbonate levels. Only potassium levels remained significant (P = 0.037). In conclusion, ARF has a high incidence, morbidity and mortality when it occurs in intensive care unit. There is a very close association with hemodynamic status and multiple organ dysfunction.

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Sepsis and SOFA score: related outcome for critically ill renal patients

Cited by 15 publications

References 0 publications

Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels

Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels

The Japanese Clinical Practice Guideline for acute kidney injury 2016

Incidence, risk factors and prognostic factors of acute renal failure in patients admitted to an intensive care unit

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