Sepsis and the heart

Hunter, J. D.; Doddi, M.

doi:10.1093/bja/aep339

Cited by 222 publications

(152 citation statements)

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“…Sepsis is usually known to depress cardiac function (Hunter and Doddi 2010). In humans, changes are difficult to estimate, since the measurements are performed in inactive patients whose cardiac activity is low.…”

Section: Discussionmentioning

confidence: 99%

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Early sepsis does not stimulate reactive oxygen species production and does not reduce cardiac function despite an increased inflammation status

et al. 2017

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If it is sustained for several days, sepsis can trigger severe abnormalities of cardiac function which leads to death in 50% of cases. This probably occurs through activation of toll‐like receptor‐9 by bacterial lipopolysaccharides and overproduction of proinflammatory cytokines such as TNF‐α and IL‐1β. In contrast, early sepsis is characterized by the development of tachycardia. This study aimed at determining the early changes in the cardiac function during sepsis and at finding the mechanism responsible for the observed changes. Sixty male Wistar rats were randomly assigned to two groups, the first one being made septic by cecal ligation and puncture (sepsis group) and the second one being subjected to the same surgery without cecal ligation and puncture (sham‐operated group). The cardiac function was assessed in vivo and ex vivo in standard conditions. Several parameters involved in the oxidative stress and inflammation were determined in the plasma and heart. As evidenced by the plasma level of TNF‐α and gene expression of IL‐1β and TNF‐α in the heart, inflammation was developed in the sepsis group. The cardiac function was also slightly stimulated by sepsis in the in vivo and ex vivo situations. This was associated with unchanged levels of oxidative stress, but several parameters indicated a lower cardiac production of reactive oxygen species in the septic group. In conclusion, despite the development of inflammation, early sepsis did not increase reactive oxygen species production and did not reduce myocardial function. The depressant effect of TNF‐α and IL‐1β on the cardiac function is known to occur at very high concentrations. The influence of low‐ to moderate‐grade inflammation on the myocardial mechanical behavior must thus be revisited.

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Section: Discussionmentioning

confidence: 99%

“…2012). The up‐to‐date measurement techniques of cardiac function (echography, MRI) do not reveal important modifications of this parameter during sepsis, except a decrease in diastolic function followed by a reduction of systolic function in the sickest patients (Hunter and Doddi 2010; Flynn et al. 2010).…”

Section: Introductionmentioning

confidence: 99%

Early sepsis does not stimulate reactive oxygen species production and does not reduce cardiac function despite an increased inflammation status

et al. 2017

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“…Chronic inflammation is one of the leading causes of mortality in the western world and is associated with several pathologies like cancer (Porta et al, 2009), rheumatoid arthritis, diabesity (Schmidt and Duncan, 2003), cardiovascular and neurodegenerative diseases (Hunter and Doddi, 2010;Whitney et al, 2009). However, the current anti-inflammatory drugs have several limitations such as lack of responsiveness, side effects, delivery problems and cost of manufacture.…”

Section: Introductionmentioning

confidence: 99%

Cymbopogon citratus as source of new and safe anti-inflammatory drugs: Bio-guided assay using lipopolysaccharide-stimulated macrophages

Francisco

Figueirinha

Neves

et al. 2011

Journal of Ethnopharmacology

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Please cite this article as: Francisco, V., Figueirinha, A., Neves, B.M., García-Rodríguez, C., Lopes, M.C., Cruz, M.T., Batista, M.T., Cymbopogon citratus as source of new and safe anti-inflammatory drugs: bio-guided assay using lipopolysaccharide-stimulated macrophages, Journal of Ethnopharmacology (2010Ethnopharmacology ( ), doi:10.1016Ethnopharmacology ( /j.jep.2010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Page 1 of 30A c c e p t e d M a n u s c r i p t 1 Graphical abstractIn this report it was demonstrated that a lipid-and essential oil-free infusion of Cymbopogon citratus leaves (Cy), as well its polyphenols, have anti-inflammatory properties through inhibition of proinflammatory signaling pathways and nitric oxide production in lipopolysaccharide-stimulated macrophages. These evidences support the use of Cymbopogon citratus in traditional medicine and indicate that it could be a natural source of new and safe anti-inflammatory drugs. TitleCymbopogon citratus as source of new and safe anti-inflammatory drugs: bio-guided assay using lipopolysaccharide-stimulated macrophages Aim of the study: The aim of this study is to explore the anti-inflammatory properties of Cymbopogon citratus leaves and their polyphenol-rich fractions (PFs), as well its mechanism of action in murine macrophages. Materials and Methods:A lipid-and essential oil-free infusion of Cy leaves was prepared (Cy extract) and fractionated by column chromatography. Anti-inflammatory properties of Cy extract (1.115 mg/ml) and its PFs, namely phenolic acids (530 µg/ml), flavonoids (97.5 µg/ml) and tannins (78 µg/ml), were investigated using lipopolysaccharide (LPS)-stimulated Raw 264.7 macrophages as in vitro model. As inflammatory parameters, nitric oxide (NO) production was evaluated by Griess reaction, as well as effects on cyclooxygenase (COX-2), inducible NO synthase (iNOS) expression and on intracellular signaling pathways activation, which were analyzed by Western blot using specific antibodies. Page 3 of 30A c c e p t e d M a n u s c r i p t Conclusions: Our data provide evidence that support the usage of Cymbopogon citratus leaves extract in traditional medicine, and suggest that Cy, in particular its polyphenolic compounds, could constitute a natural source of a new and safe anti-inflammatory drugs.

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“…Earlier studies [6] note survivors of septic cardiomyopathy have significantly more dilated left ventricles (LV) and decreased ejection fractions (EF) relative to non-survivors [6]. However, newer literature has shown that lower ejection fractions translate into poorer prognoses [2].…”

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confidence: 99%

“…Studies performed on rodent models of sepsis show significant decreases in measures of contractility in cardiomyocytes exposed in vitro to TNF-α, IL-1β [8], and IL-6 [9]. Accordingly, patients with sepsis demonstrate higher levels of interleukins and complement components in their bloodstream [2].…”

mentioning

confidence: 99%