Sepsis-Induced Acute Kidney Injury in Equine: Current Knowledge and Future Perspectives

Aamer, Haytham G.; El-Ashker, Maged; Nour, Eman M.; Wafa, Ehab W.; Youssef, Mohamed A.

doi:10.1016/j.jevs.2016.11.006

Cited by 3 publications

(4 citation statements)

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“…Sepsis could not be definitively ruled out as a contributing factor to AKI in this case (Aamer et al . 2017). Low circulating bacterial numbers or antibiotic use may have influenced the negative blood culture result (Stewart et al .…”

Section: Discussionmentioning

confidence: 99%

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Oxytetracycline associated acute kidney injury in a neonatal foal

Fletcher

Bertin

Owen

et al. 2020

Equine Veterinary Education

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Summary A 3‐day‐old Australian Stock Horse filly presented with fulminant acute kidney injury after receiving 4 g of intravenous oxytetracycline at 24 and 48 h of age for medical management of flexural deformities. The filly’s clinical status initially improved, but worsening azotaemia prompted euthanasia after 55 h of supportive care. Necropsy confirmed proximal tubular necrosis. Nephropathy in association with oxytetracycline administration has been rarely reported. This case describes severe nephropathy in an apparently normal foal and highlights the need for thorough case evaluation prior to use of high‐dose oxytetracycline therapy for correction of flexural deformities in foals.

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Section: Discussionmentioning

confidence: 99%

“…Possible differential diagnoses for obtundation included sepsis (Aamer et al . 2017), hyponatraemic encephalopathy (Collins et al . 2016) or neonatal maladjustment syndrome (Wong et al .…”

Section: Discussionmentioning

confidence: 99%

Oxytetracycline associated acute kidney injury in a neonatal foal

Fletcher

Bertin

Owen

et al. 2020

Equine Veterinary Education

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“…through increases in serum NGAL concentrations caused by concurrent or unrelated disease. Acute kidney injury is known to cause increased blood levels of NGAL [17,18], and AKI may develop in foals with sepsis [19]. However, in septic human neonates, serum and urinary NGAL concentrations have been found to correlate strongly to the degree of systemic inflammation and not so much to the presence of AKI [20].…”

Section: Plos Onementioning

confidence: 99%

Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals

Laurberg,

Saegerman,

Jacobsen

et al. 2023

PLoS ONE

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Background Equine neonatal sepsis can be challenging to diagnose and prognosticate. Neutrophil gelatinase-associated lipocalin (NGAL), a new marker of renal damage and inflammation, can potentially be helpful. Objectives To evaluate NGAL in neonatal foals with sepsis, and assess its relation to outcome. Animals Foals ≤ 14 days, with admission blood analysis and stored serum. Methods NGAL was measured on stored serum from 91 foals. Foals were scored for sepsis and survival and categorized according to sepsis status (septic, sick non-septic, healthy, and uncertain sepsis status) and outcome groups (survivors and non-survivors). The septic foals were further sub-categorized according to severity (normal sepsis, severe sepsis and septic shock). A Kruskal-Wallis test was used to compare serum NGAL concentrations in survivors and non-survivors, in the sepsis status groups, and in the sepsis severity groups. Optimal cut-off values for serum NGAL concentrations to diagnose sepsis and outcome were determined with receiver operating characteristic (ROC) curves. NGAL was compared to creatinine and SAA. Results Median serum NGAL concentrations were significantly higher in septic than non-septic foals. However, serum NGAL concentrations did not differ between sepsis severity subgroups. Serum NGAL concentrations were significantly lower in survivors than in non-survivors. Optimal cut-off values of serum NGAL concentrations were 455 μg/L (sensitivity 71.4%, specificity 100%) and 1104 μg/L (sensitivity 39.3%, specificity 95.2%) for predicting sepsis and non-survival, respectively. NGAL correlated to SAA, but not to creatinine. NGAL performed similarly to SAA to diagnose sepsis. Conclusion Serum NGAL concentrations may be useful for diagnosing sepsis and predicting outcome.

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“…Ebenso lagen moderate Korrelationen zwischen Harnstoff und der uGGT/uKreatinin Ratio vor (r = 0,376). (Aamer et al 2017, Brobst und Bayly 1982. Zu welchem Zeitpunkt die Dehydratation der vorliegenden Studie untersuchten Pferde genau begann, konnte nicht rückgeschlossen werden.…”

Section: Studiendesign Und -Populationunclassified