2018
DOI: 10.1097/shk.0000000000001076
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Sepsis Induces Adipose Tissue Browning in Nonobese Mice But Not in Obese Mice

Abstract: Severe sepsis and septic shock are the biggest cause of mortality in critically ill patients. Obesity today is one of the world’s greatest health challenges. Little is known about the extent of involvement of the white adipose tissue (WAT) in sepsis and how it is being modified by obesity. We sought to explore the involvement of the WAT in sepsis. We hypothesize that sepsis induces browning of the WAT and that obesity alters the response of WAT to sepsis. Six-week old C57BL/6 mice were randomized to a high fat… Show more

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Cited by 18 publications
(16 citation statements)
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“…Secondly, an increase in catecholamines and subsequent stimulation of β-ARs might promote the browning of WAT. 37 Previous data stated a decrease in β-AR subtypes in obesity, which may partly clarify the lack of WAT browning in obese septic mice. 58 Additionally, it was stated that BAT is more resistant to developing obesity-induced inflammation compared with WAT.…”
Section: Obesity and Adipose Tissue Browningmentioning
confidence: 95%
See 3 more Smart Citations
“…Secondly, an increase in catecholamines and subsequent stimulation of β-ARs might promote the browning of WAT. 37 Previous data stated a decrease in β-AR subtypes in obesity, which may partly clarify the lack of WAT browning in obese septic mice. 58 Additionally, it was stated that BAT is more resistant to developing obesity-induced inflammation compared with WAT.…”
Section: Obesity and Adipose Tissue Browningmentioning
confidence: 95%
“…A mice model of CLP‐induced sepsis showed a marked increase in the formation of smaller sized lipid droplets from large droplets in mice without obesity compared with those with obesity. Additionally, a decrease in adipocytes size, increase in mitochondrial density, appearance of mitochondria near lipid droplets, up‐regulation of UCP1 and adipose tissue browning were observed in non‐obese but not in obese septic mice 37 (Figure 2). Two hypotheses were suggested for these findings.…”
Section: Obesity and Adipose Tissue Browningmentioning
confidence: 95%
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“…However, the data are far from conclusive and mechanistic explanations are lacking. Indeed, basic studies in mice suggest that diet-induced obesity increases sepsis-induced inflammation as well as injury to the heart and liver ( 66 69 ).…”
Section: Overview Of the Presentationmentioning
confidence: 99%