Septal Vasopressin Modulates Motility and Passive Avoidance in Pinealectomized Rats

Appenrodt, E.; Schwarzberg, H

doi:10.1016/s0031-9384(99)00013-x

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Consistent with this evidence, another research has also shown that pinealectomy did not have a significant role on the acquisition and extinction of the active avoidance behaviour (Appenrodt and Schwarzberg 2003). In a similar vein, other studies that focused on some behavioural measures such as anxiety behaviour (Appenrodt and Schwarzberg 2000), passive avoidance learning (Appenrodt and Schwarzberg 1999), open-field exploratory activity (Kova´cs et al 1974) and social recognition (Appenrodt et al in the Morris water maze are represented. Right striated bar represents melatonin injection (Mel.…”

Section: Discussionmentioning

confidence: 54%

“…lesion on habenula) did impair cognitive performance (Lecourtier et al 2005). A great number of studies have consistently demonstrated that pinealectomy did not have a significant role on the acquisition and extinction of the active avoidance behaviour (Appenrodt and Schwarzberg 2003), anxiety behaviour (Appenrodt and Schwarzberg 2000), passive avoidance learning (Appenrodt and Schwarzberg 1999), open-field exploratory activity (Kova´cs et al 1974) and social recognition (Appenrodt et al 2002). On the other hand, whether or not pinealectomy decreases the learning capacity on the Morris water maze is still not known, and no published research has been reported about it so far.…”

Section: Introductionmentioning

confidence: 99%

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The effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar rats

Karakaş

Coşkun

Kaya

2011

Biological Rhythm Research

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Melatonin is the main hormone of the pineal gland that informs the body about the environmental light and darkness regimen and is considered to regulate many important physiological and behavioural activities. In the present study, we examined the effects of pinealectomy, constant-release melatonin implants and timed melatonin injections on spatial memory in male Wistar rats by using Morris water maze. Pinealectomy, melatonin injection and melatonin implantation were performed on groups, including controls for all groups. After a week of the pinealectomy and melatonin implantation surgeries, we applied the injections and made the training trials throughout 4 days. At the fifth day, experiments were performed and recorded. Spatial memory performance of the rats was impaired by the pinealectomy and melatonin injections, since they elongated the latency and shortened the time passed in the correct quadrant. Melatonin implantation did not affect the spatial memory performance of the rats. The latency and the time passed in correct quadrant were not statistically different from their controls. The results suggest that while the removal of the pineal gland and exogenous administration of melatonin via injections are causing impairment, constantrelease melatonin administration via implantation does not affect the spatial memory in Wistar albino rats.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

The effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar rats

Karakaş

Coşkun

Kaya

2011

Biological Rhythm Research

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“…For instance, while the pinealectomy itself did not have a detrimental effect on cognitive performance in rats, the interaction of it with the other lesion (i.,e, lesion on habenula) impaired such performance (Lecourtier et al, 2005). Many studies have shown that pinealectomy did not have a significant effect on the acquisition and extinction of the active avoidance behavior (Appenrodt and Schwarzberg, 2003), anxiety behavior (Appenrodt and Schwarzberg, 2000), passive avoidance learning (Appenrodt and Schwarzberg, 1999), open field exploratory activity (Kovács et al, 1974), and social recognition (Appenrodt et al, 2002).…”

Section: Pinealectomymentioning

confidence: 99%

Intraamygdalar Melatonin Administration and Pinealectomy Affect Anxiety Like Behavior and Spatial Memory

Karakaş¹,

Coşkun²

2012

Neuroendocrinology and Behavior

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“…Arginine vasopressin (AVP) has numerous important roles in the central regulation of behavior. Specific brain sites of action have been implicated in the control of some defined behaviors, including motility and passive avoidance (Appenrodt & Schwarzberg, ; Schwarzberg & Appenrodt, ), aggression (Ferris & Potegal, ; Ferris et al ., , ; Ferris, ; Gutzler et al ., ), the stress response (Koob et al ., ; Engelmann et al ., ), learning and memory (Koob et al ., ; Van Wimersma Greidanus & Veldhuis, ; Bluthe & Dantzer, ; Paban et al ., ), flank marking (Ferris et al ., , , ; Albers & Ferris, ; Albers et al ., ; Irvin et al ., ; Hennessey & Albers, ; Bamshad & Albers, ), and social recognition (Albers et al ., ; Bluthe & Dantzer, ; Landgraf et al ., ; Albers & Bamshad, ).…”

Section: Introductionmentioning

confidence: 99%

Suprachiasmatic vasopressin and the circadian regulation of voluntary locomotor behavior

Cormier

Della‐Maggiore

Karatsoreos

et al. 2014

Eur J of Neuroscience

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A role for arginine vasopressin in the circadian regulation of voluntary locomotor behavior (wheel running activity) was investigated in the golden hamster, Mesocricetus auratus. Spontaneous nocturnal running was suppressed in a dose-dependent manner by systemic injections of vasopressin, and also in a concentration-dependent manner by microinjections directly into the hypothalamic suprachiasmatic nucleus. Pre-injections of a vasopressin V1 receptor antagonist into the nucleus reduced the suppression of behavior by vasopressin. Ethogram analyses revealed that peripheral drug injections predominantly increased grooming, flank marking, and sleep-related behaviors. Central injections did not induce sleep, but increased grooming and periods of 'quiet vigilance' (awake but not moving). Nocturnal behavioral profiles following either peripheral or central injections were similar to those shown by untreated animals in the hour prior to the onset of nocturnal wheel running. Site control vasopressin injections into the medial preoptic area or periaqueductal gray increased flank marking and grooming, but had no significant effect on locomotion, suggesting behavioral specificity of a vasopressin target near the suprachiasmatic nucleus. Both peripheral and central administration increased FOS-like immunoreactivity in the retinorecipient core of the suprachiasmatic nucleus. The distribution of FOS-positive cells overlapped the calbindin subregion, but was more extensive, and most calbindin-positive cells did not co-express FOS. We propose a model of temporal behavioral regulation wherein voluntary behavior, such as nocturnal locomotor activity, is inhibited by the activity of neurons in the suprachiasmatic ventrolateral core that project to the posterior hypothalamus and are driven by rhythmic vasopressin input from the dorsomedial shell.

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Septal Vasopressin Modulates Motility and Passive Avoidance in Pinealectomized Rats

Cited by 6 publications

References 29 publications

The effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar rats

The effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar rats

Intraamygdalar Melatonin Administration and Pinealectomy Affect Anxiety Like Behavior and Spatial Memory

Suprachiasmatic vasopressin and the circadian regulation of voluntary locomotor behavior

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