Septic arthritis caused by gout progressed to sepsis and hemophagocytic syndrome

Yang, Wei; Yang, Chun

doi:10.1016/j.heliyon.2024.e30583

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e30583

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Septic arthritis caused by gout progressed to sepsis and hemophagocytic syndrome

Wei Yang,

Chun Yang

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2024

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Unforeseen Barrier in Gout Treatment: A Case of Coexisting Lyme Disease

Smiyan,

Komorovsky,

Koshak

et al. 2024

AAEE

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Refractory gout and Lyme disease are distinct conditions that, when coexisting, pose significant diagnostic and therapeutic challenges, particularly in regions endemic for Lyme disease. This case report presents a 49-year-old male with a three-year history of gout, presenting with acute arthritis of the first metatarsophalangeal joint, unresponsive to standard urate-lowering therapy. Despite treatment with colchicine and prednisone, the patient’s symptoms persisted, and inflammatory markers remained elevated. Imaging revealed findings consistent with gouty arthritis, but due to the atypical treatment response, further testing was conducted. Serological analysis confirmed infection with Borrelia burgdorferi, establishing the diagnosis of concurrent Lyme disease. The addition of doxycycline to the treatment regimen resulted in significant clinical improvement within days. This case highlights the importance of considering Lyme disease in patients with refractory gout in areas endemic for Lyme disease. While rare cases of Lyme disease mimicking gout have been reported, this is among the first documented instances of their coexistence. Early recognition and appropriate antibiotic treatment are critical in preventing complications and ensuring optimal management of both conditions.

show abstract

Unforeseen Barrier in Gout Treatment: A Case of Coexisting Lyme Disease

Smiyan,

Komorovsky,

Koshak

et al. 2024

AAEE

View full text Add to dashboard Cite

show abstract

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Septic arthritis caused by gout progressed to sepsis and hemophagocytic syndrome

Cited by 1 publication

References 4 publications

Unforeseen Barrier in Gout Treatment: A Case of Coexisting Lyme Disease

Unforeseen Barrier in Gout Treatment: A Case of Coexisting Lyme Disease

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