Septic Arthritis in Emergency Departments in the <scp>US</scp>: A National Study of Health Care Utilization and Time Trends

Singh, Jasvinder A.; Yu, Shaohua

doi:10.1002/acr.23270

Cited by 32 publications

(18 citation statements)

References 13 publications

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“…In addition, OA consumes a substantial amount of healthcare resources and costs. Studies have demonstrated that OA was associated with higher risk of hospitalization and emergency department charges among those who present in the emergency room for other reasons [25,26]. The average direct cost of OA in Canada increased from $577 to $811 per patient/year between 2003-2010, primarily due to joint replacement surgery costs [27].…”

Section: Impact Of Osteoarthritismentioning

confidence: 99%

Epidemiology of osteoarthritis: literature update

Vina

Kwoh

2018

Current Opinion in Rheumatology

757

517

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Section: Impact Of Osteoarthritismentioning

confidence: 99%

Epidemiology of osteoarthritis: literature update

Vina

Kwoh

2018

Current Opinion in Rheumatology

757

517

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“…In fact, it has been estimated that 30 percent of all patients surviving SA suffer from chronic joint damage eventually causing invalidity ( 14 , 15 ). The mortality of this disorder remains continuously high and research data defining the pathogenesis of SA are limited ( 11 , 16 – 18 ). In particular, the significance of pre-existing joint disorders for the onset and progression of SA remains obscure, despite epidemiological studies pointing toward autoimmune joint diseases as risk factors ( 13 , 16 , 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Joint Disease Is a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice

et al. 2020

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Septic arthritis is a medical emergency associated with high morbidity and mortality, yet hardly any novel advances exist for its clinical management. Despite septic arthritis being a global health burden, experimental data uncovering its etiopathogenesis remain scarce. In particular, any interplay between septic arthritis and preceding joint diseases are unknown as is the contribution of the synovial membrane to the onset of inflammation. Using C57BL/6 mice as a model to study sepsis, we discovered that Group A Streptococcus (GAS) – an important pathogen causing septic arthritis - was able to invade the articular microenvironment. Bacterial invasion resulted in the infiltration of immune cells and detrimental inflammation. In vitro infected fibroblast-like synoviocytes induced the expression of chemokines ( Ccl2 , Cxcl2 ), inflammatory cytokines ( Tnf , Il6 ), and integrin ligands (ICAM-1, VCAM-1). Apart from orchestrating immune cell attraction and retention, synoviocytes also upregulated mediators impacting on bone remodeling ( Rankl ) and cartilage integrity ( Mmp13 ). Using collagen-induced arthritis in DBA/1 × B10.Q F1 mice, we could show that an inflammatory joint disease exacerbated subsequent septic arthritis which was associated with an excessive release of cytokines and eicosanoids. Importantly, the severity of joint inflammation controlled the extent of bone erosions during septic arthritis. In order to ameliorate septic arthritis, our results suggest that targeting synoviocytes might be a promising approach when treating patients with inflammatory joint disease for sepsis.

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“…Septic arthritis is an orthopedic emergency requiring urgent joint washout and antibiotics. On average, admissions for septic arthritis typically last a week [6]. Given the time course of symptom resolution, negative cultures, no recent sexual history, and negative gonorrhea and chlamydia testing, gonococcal and non-gonococcal arthritis was less likely.…”

Section: Discussionmentioning

confidence: 99%

Acute Rheumatic Fever Presenting as a Mimicker of Septic Arthritis

Achebe

Hussain

Abraham

et al. 2020

Cureus

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Acute rheumatic fever (ARF) describes the non-suppurative and autoimmune inflammation of joint, muscle, and fibrous tissue that occurs after group A streptococcal (GAS) pharyngitis. This report describes a rare case of a 39-year-old male with migratory arthralgias as a presenting sign of ARF. Through this case, we review the current literature on ARF and highlight clinical and objective findings that differentiate ARF from similar presenting arthralgias, specifically post-streptococcal reactive arthritis (PSRA). With this report, we hope to increase clinical suspicion for ARF in patients with acute joint pain, as differentiating ARF from other arthritides, PSRA specifically, determines management strategy and need for secondary prophylaxis against rheumatic heart disease.

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Septic Arthritis in Emergency Departments in the US: A National Study of Health Care Utilization and Time Trends

Abstract: Comorbidities were associated with a higher risk of hospitalization after an ED visit for septic arthritis, but not higher ED charges. No time trends in ED visit incidence, ED charges, or hospitalization rate for septic arthritis from 2009-2012 were noted.

Cited by 32 publications

References 13 publications

Epidemiology of osteoarthritis: literature update

Epidemiology of osteoarthritis: literature update

Inflammatory Joint Disease Is a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice

Acute Rheumatic Fever Presenting as a Mimicker of Septic Arthritis

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