2017
DOI: 10.1159/000475847
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Septic Complications after Resection for Middle or Low Rectal Cancer: Role of Gut Barrier Function and Inflammatory Serum Markers

Abstract: Background: The focus of this study was to understand the relationship between the failure of gut barrier function, inflammatory markers and septic complications after resection for extraperitoneal rectal cancer. Methods: One hundred seven patients were enrolled into this prospective observational study and underwent open colorectal resection for extraperitoneal cancer. All patients underwent an assessment of intestinal permeability (L/M ratio), endotoxemia, interleukin-1β (IL-1β), interleukin-6 (IL-6), C-reac… Show more

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Cited by 15 publications
(9 citation statements)
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“…Mucous secretions are rich in secretory IgA, which neutralizes toxins and microorganisms and prevents their adhesion and colonization [47]. Any disturbances in microcirculation of the intestinal mucosa lead to hypoperfusion, edema of the mucous membrane, its ischemia, an increase in free oxygen radicals that destroy the cytoskeleton of the mucous membrane, which contributes to the disruption of the integrity of the intestinal barrier and subsequent bacterial translocation [48][49][50][51][52].…”
Section: Violation Of the Barrier Function Of The Intestinal Mucosamentioning
confidence: 99%
“…Mucous secretions are rich in secretory IgA, which neutralizes toxins and microorganisms and prevents their adhesion and colonization [47]. Any disturbances in microcirculation of the intestinal mucosa lead to hypoperfusion, edema of the mucous membrane, its ischemia, an increase in free oxygen radicals that destroy the cytoskeleton of the mucous membrane, which contributes to the disruption of the integrity of the intestinal barrier and subsequent bacterial translocation [48][49][50][51][52].…”
Section: Violation Of the Barrier Function Of The Intestinal Mucosamentioning
confidence: 99%
“…In the absence of established guidelines, the decision whether to restore bowel continuity arises from the consensus between the surgeon and the patient after discussion on the possible benefits and risks associated with the procedure. In this perspective, young age, low American Society of Anesthesiologists (ASA) score, low comorbidity, benign disease, male gender, and high-volume surgeons are factors associated both with a better peri-operative outcome and a higher reversal rate [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Scientific data, focused on the effect of time from the initial procedure up to the restoration on early and late outcomes, are still lacking.…”
Section: Introductionmentioning
confidence: 99%
“…Cytokines such as tumor necrosis factor (TNF) and interleukins (ILs) are closely associated with the differentiation and proliferation of tumor cells and the formation of tumor neovascularization ( 4 ), which has an important impact on the progression of patients with tumor. They can be used as a reference index for the clinical outcome and follow-up of patients with colorectal cancer ( 5 ). The progression and metastasis of tumors depend on tumor blood vessels.…”
Section: Introductionmentioning
confidence: 99%