Septic funiculitis caused by<i><scp>S</scp>treptococcus equi</i>subspecies<i>equi</i>infection with associated immune‐mediated haemolytic anaemia

Caniglia, C J; Davis, Jennifer L.; Schott, H. C.; Brakenhoff, J. E.

doi:10.1111/eve.12116

Cited by 9 publications

(9 citation statements)

References 26 publications

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“…Immunosuppressive doses of systemic corticosteroids are recommended for the treatment of IMHA (Caniglia et al . ), particularly if there is progression of immune‐mediated haemolysis, as occurred in this case. Treatment should gradually be tapered and eventually discontinued.…”

Section: Discussionmentioning

confidence: 65%

Successful management of multiple extrapulmonary complications associated with Rhodococcus equi pneumonia in a foal

Wilkes

Hughes

Kessell

et al. 2015

Equine Veterinary Education

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Summary This report describes the diagnosis and successful treatment of multiple extrapulmonary sequelae of Rhodococcus equi (R. equi) pneumonia in a 3‐month‐old filly. Bilateral uveitis and hyphaema, haemolytic anaemia and polysynovitis developed in this foal and were likely due to immune‐mediated mechanisms. The challenges associated with diagnosis and treatments of these extrapulmonary disorders are discussed. The filly was treated initially with clarithromycin and rifampin; however, a blood transfusion and immunosuppressive therapy with dexamethasone were required due to progressive haemolysis and for treatment of uveitis and polysynovitis. Bilateral hyphaema was successfully treated with intracameral injections of a recombinant tissue plasminogen activator. The development of antimicrobial resistance in R. equi was an additional challenge encountered in the management of this case and emphasises the importance of culture and in vitro antimicrobial susceptibility testing of isolates from foals with R. equi pneumonia. Extrapulmonary disorders associated with R. equi pneumonia are likely underdiagnosed and associated with a poor prognosis. This case highlights the importance of thorough and ongoing diagnostic assessment of foals with R. equi pneumonia and demonstrates that a successful outcome can be achieved with appropriate and directed treatment.

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Section: Discussionmentioning

confidence: 65%

Successful management of multiple extrapulmonary complications associated with Rhodococcus equi pneumonia in a foal

Wilkes

Hughes

Kessell

et al. 2015

Equine Veterinary Education

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“…Horses with infection in the sinuses may become carriers. Other reported sequelae associated with S. equi infection include anemia, agalactia, myocarditis, endocarditis, panophthalmitis, periorbital abscesses, ulcerative keratitis, paravertebral abscesses, meningitis, funiculitis, septic arthritis, and tenosynovitis …”

Section: Treatmentmentioning

confidence: 99%

Streptococcus equiInfections in Horses: Guidelines for Treatment, Control, and Prevention of Strangles—Revised Consensus Statement

Boyle

Timoney

Newton

et al. 2018

Veterinary Internal Medicne

144

284

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This consensus statement update reflects our current published knowledge and opinion about clinical signs, pathogenesis, epidemiology, treatment, complications, and control of strangles. This updated statement emphasizes varying presentations in the context of existing underlying immunity and carrier states of strangles in the transmission of disease. The statement redefines the “gold standard” for detection of possible infection and reviews the new technologies available in polymerase chain reaction diagnosis and serology and their use in outbreak control and prevention. We reiterate the importance of judicious use of antibiotics in horses with strangles. This updated consensus statement reviews current vaccine technology and the importance of linking vaccination with currently advocated disease control and prevention programs to facilitate the eradication of endemic infections while safely maintaining herd immunity. Differentiation between immune responses to primary and repeated exposure of subclinically infected animals and responses induced by vaccination is also addressed.

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“…14 Other rarely reported infections include meningitis, myocarditis, endocarditis, panophthalmitis, keratitis, funiculitis, and septic arthritis. [15][16][17][18][19] There is anecdotal suggestion that the use of antimicrobial therapy early in the course of an uncomplicated strangles infection predisposes to the development of metastatic abscesses and other complications. This is suggested to occur because of decreased stimulation of cell-mediated immunity, secondary to decreased bacterial protein synthesis.…”

Section: Complicationsmentioning

confidence: 99%

Update on Streptococcus equi subsp equi Infections

Mallicote

2015

Veterinary Clinics of North America: Equine Practice

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Septic funiculitis caused byStreptococcus equisubspeciesequiinfection with associated immune‐mediated haemolytic anaemia

Cited by 9 publications

References 26 publications

Successful management of multiple extrapulmonary complications associated with Rhodococcus equi pneumonia in a foal

Successful management of multiple extrapulmonary complications associated with Rhodococcus equi pneumonia in a foal

Streptococcus equiInfections in Horses: Guidelines for Treatment, Control, and Prevention of Strangles—Revised Consensus Statement

Update on Streptococcus equi subsp equi Infections

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