Septic shock due to Yersinia pseudotuberculosis infection in an adult immunocompetent patient: a case report and literature review

Abstract

Background Yersinia pseudotuberculosis infection can occur in an immunocompromised host. Although rare, bacteremia due to Y. pseudotuberculosis may also occur in immunocompetent hosts. The prognosis and therapeutic strategy, especially for immunocompetent patients with Y. pseudotuberculosis bacteremia, however, remains unknown. Case presentation A 38-year-old Japanese man with a mood disorder presented to our hospital with fever and diarrhea. Chest computed tomography revealed consolidation in the right upper lobe with air bronchograms. He was diagnosed with pneumonia, and treatment with intravenous ceftriaxone and azithromycin was initiated. The ceftriaxone was replaced with doripenem and the azithromycin was discontinued following the detection of Gram-negative rod bacteria in 2 sets of blood culture tests. The isolated Gram-negative rod bacteria were confirmed to be Y. pseudotuberculosis. Thereafter, he developed septic shock. Doripenem was switched to cefmetazole, which was continued for 14 days. He recovered without relapse. Conclusions We herein report a case of septic shock due to Y. pseudotuberculosis infection in an adult immunocompetent patient. The appropriate microorganism tests and antibiotic therapy are necessary to treat patients with Y. pseudotuberculosis bacteremia.

Yersinia pseudotuberculosis bacteraemia with splenic abscesses: a case report

“…Currently available reports of Y. pseudotuberculosis infections describe great variability in the extent of disease severity. Severe manifestations include bacteraemia with or without septic shock, hepatic or splenic abscesses, and rarely facet joint infections and septic arthritis [2,10].…”

The Assessment on Synergistic Activity of Ebselen and Silver Ion Against Yersinia pseudotuberculosis

“…The study of the Gram-negative zoonotic bacteria Y. pseudotuberculosis has been at the forefront of cellular and molecular pathogenesis for over four decades ( Davidson and Davis, 2020 ). Since Y. pseudotuberculosis has a very diverse host spectrum, it can infect virtually all warm-blooded animals, including humans, livestock, pets, and wild animals ( Hashimoto et al, 2021 ). Therefore, given the growing fascination of human populations with wildlife (such as game meat), the pseudotuberculosis can be expected to increase.…”

A rare Danish case of Yersinia pseudotuberculosis pyogenic liver abscess

“…8 with Y. pseudotuberculosis is rare, but have been described in patients with underlying medical conditions such as diabetes mellitus, malignancy, iron overload, and liver disease. 1,2 Though uncommon, infections with Y. pseudotuberculosis disseminated through the blood stream have been described, including hepatic, 9-14 splenic 13,15 and pulmonary abscesses, 16 peritonitis, 2 myocarditis, 2 osteomyelitis, 17 septic shock, 18 and meningitis. 2 Here, we describe the first Danish case of Y. pseudotuberculosis PLA in a patient with newly diagnosed diabetes mellitus.…”