Septic Shock in Pyogenic Liver Abscess: Clinical Considerations

Cho, A Reum; Lee, Tae Hee; Park, Min Ji; Oh, Sun Hee; Lee, Joo Ah; Park, Joo-Ho; Ryu, Ki Hyun; Koo, Hoon Sup; Song, Kyung Ho; Kim, Sun Moon; Huh, Kyu Chan; Choi, Young Woo; Kang, Young Woo

doi:10.4166/kjg.2016.67.5.245

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…In a previous report, 47 patients with PLA had markedly elevated CRP levels (mean, 27.2 mg/dL) (8). Cho et al reported that a high CRP level was a risk factor for septic shock in patients with PLA (41). Furthermore, in a Japanese retrospective multicenter study on 25 patients with EE (32 eyes), Todokoro et al reported that an elevated body temperature (64%), high serum CRP (96%), and leukocytosis (52%) were frequently observed (22).…”

Section: Discussionmentioning

confidence: 99%

Endogenous Endophthalmitis Associated with Pyogenic Liver Abscess Caused by <i>Klebsiella pneumoniae</i>

et al. 2019

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We report 2 cases of endogenous endophthalmitis associated with pyogenic liver abscess caused by Klebsiella pneumoniae. Case 1 involved a 70-year-old woman and case 2 involved a 50-year-old man who were admitted to our hospital with diagnoses of liver abscess and endogenous endophthalmitis, respectively. The liver abscess resolved with antibiotics and percutaneous transhepatic drainage in case 1 and with antibiotics alone in case 2. Even though both cases underwent ophthalmic surgery, they were discharged from our hospital without the recovery of their eyesight. An earlier diagnosis and treatment are needed to improve the prognosis of endophthalmitis.

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Section: Discussionmentioning

confidence: 99%

Endogenous Endophthalmitis Associated with Pyogenic Liver Abscess Caused by <i>Klebsiella pneumoniae</i>

et al. 2019

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“…Despite the various changes in liver abscess regarding its causes and risk factors, the management of PLA in Korea has not been updated correspondingly, and only a few studies on PLA in Korea since the mid‐2010s have been conducted. Since 2010, only six cohort results from a single centre have been reported 7,14‐18 . Therefore, it was impossible to calculate the population‐based incidence.…”

Section: Introductionmentioning

confidence: 99%

“…Since 2010, only six cohort results from a single centre have been reported. 7,[14][15][16][17][18] Therefore, it was impossible to calculate the population-based incidence. Moreover, prior to this study, there has been no population-based study in Korea.…”

mentioning

confidence: 99%

A population‐based study of pyogenic liver abscess in Korea: Incidence, mortality and temporal trends during 2007‐2017

Yoo

Lee

Kyoung

et al. 2021

Liver International

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Background/Aims Although the epidemiology of pyogenic liver abscess (PLA) continues to change, only a few population‐based studies have been conducted in Korea. This study investigated the epidemiology and clinical outcomes of PLA patients during a period of 10 years. Methods We analysed the Health Insurance Review and Assessment Service data between 2007 and 2017. The data included annual incidence rates, demographic data, underlying diseases, complications and mortality of PLA patients. Results The annual incidence of PLA for all age groups was 10.9 per 100 000 population. The incidence was gradually increased from 5.7 per 100 000 in 2007 to 14.4 per 100 000 in 2017. In patients with liver abscess, the prevalence of diabetes and malignancy were 37.24% and 26.5% respectively. Metastatic infection was reported in 1.74% of the patients, and endophthalmitis was most common. The mean in‐hospital mortality was 9.6%, and there was no significant difference in mortality by year during the observation period. Mortality increased with age and was greatly affected by the underlying diseases, especially cancer. Based on the multivariate analysis results, the mortality of PLA patients was associated with older age, female sex, diabetes, malignancy and chronic kidney disease. Conclusion The PLA incidence is rapidly increasing in Korea, especially in people with comorbidities. In addition, the causes and risk factors of PLA infections are changing and thus further research on epidemiology, different diagnosis and management approaches is required.

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“…Klebsiella pneumoniae infection has been shown to be an independent predictor of the development of septic shock in initially stable patients with PLA 24 . A previous study by Cho et al .…”

Section: Discussionmentioning

confidence: 99%

The Delta Neutrophil Index Predicts the Development of In-hospital Hypotension in Initially Stable Patients with Pyogenic Liver Abscess

Kong

Park

Lee

et al. 2019

Sci Rep

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Prompt diagnosis and timely treatment are important for reducing morbidity and mortality from pyogenic liver abscess (PLA). The purpose of this study was to investigate the importance of the delta neutrophil index (DNI) reflecting the fraction of immature granulocytes as a predictor of the development of in-hospital hypotension in initially stable patients with PLA. We retrospectively identified 308 consecutive patients (>18 years) who were hemodynamically stable at presentation and diagnosed with PLA in the emergency department (ED) between January 2011 and September 2017. The outcome of interest was in-hospital hypotension 1–24 hours after admission to the ED. A high DNI at ED admission was an independent predictor of the development of in-hospital hypotension in initially stable patients with PLA (odds ratio [OR]: 1.44, 95.0% confidence interval [CI]: 1.06–1.95; P = 0.02). A DNI > 3.3% was associated with in-hospital hypotension at ED admission (OR: 5.37, 95.0% CI: 2.91–9.92; P < 0.001). The development of in-hospital hypotension was associated with an increased risk of 30-day mortality (HR: 8.55, 95.0% CI: 2.57–28.4; P < 0.001). A high DNI independently predicts the development of in-hospital hypotension in initially stable patients with PLA. In-hospital hypotension is associated with an increased risk of 30-day mortality.

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Septic Shock in Pyogenic Liver Abscess: Clinical Considerations

Abstract: The presence of mental change, gas-forming abscess, and K. pneumoniae infection were independent predictors for septic shock in patients with PLA.

Cited by 6 publications

References 21 publications

Endogenous Endophthalmitis Associated with Pyogenic Liver Abscess Caused by <i>Klebsiella pneumoniae</i>

Endogenous Endophthalmitis Associated with Pyogenic Liver Abscess Caused by <i>Klebsiella pneumoniae</i>

A population‐based study of pyogenic liver abscess in Korea: Incidence, mortality and temporal trends during 2007‐2017

The Delta Neutrophil Index Predicts the Development of In-hospital Hypotension in Initially Stable Patients with Pyogenic Liver Abscess

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