Septicaemia of the Newborn, Associated With Ruptured Foetal Membranes. Discoloured Amniotic Fluid or Maternal Fever

Knudsen, Finn Ursin; STEINRUD, JANNE

doi:10.1111/j.1651-2227.1976.tb04961.x

Cited by 17 publications

(5 citation statements)

References 24 publications

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“…35 Multiple UVE (>3) increases the risk of neonatal sepsis. 34,36 Our findings (UVE >3) was consistent with other studies 24,37 & it was found to be highly significant (P<0.028).Attack rate of neonatal sepsis increases with rise of maternal intrapartum temperature; a 10 fold is documented when peak temperature rises to 38 0 C or more. Our study also found highly significant (P<0.000) relation of this factor with sepsis.…”

Section: Discussionsupporting

confidence: 81%

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Predictive Values of Risk Factors in Neonatal Sepsis

Mk¹,

Mahmood²

2012

J. Bangladesh Coll. Phys.

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Neonatal sepsis is one of the most important causes of mortality and morbidity especially in developing countries. Management of such cases is difficult, costly and need expert centers in many cases. Therefore, identification of the risk factors and their predictive values may help optimizing its management. With the above idea this case-control study was done to see the effects of maternal and neonatal risk factors and to find their predictive values in the development of neonatal sepsis. Fifty cases and fifty suitably matched controls were enrolled in the study and different maternal, natal and newborn factors were compared. Many risk factors were found to have influence in the development of neonatal sepsis. Among them the maternal intrapartum fever, foul smelling liquor, young mother (< 20 yrs), poor income group, prolonged labor, unclean vaginal examination (UVE) and primi mother were much associated with the occurrence of sepsis. Also the neonatal factors, like prematurity, resuscitation at birth and low APGAR score carried the significant risk of developing sepsis. But when relative influence of these risk factors were analyzed over neonatal sepsis in detecting their predictive values, it was found that irregular antenatal check up, prematurity, resuscitation at birth, and maternal intrapartum fever had influenced most in the development of neonatal sepsis in chronological order. DOI: http://dx.doi.org/10.3329/jbcps.v29i4.11324 J Bangladesh Coll Phys Surg 2011; 29: 187-195

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Section: Discussionsupporting

confidence: 81%

“…This is consistent with observation of other workers. Knudsen et al 37 found 20% incidence of sepsis & Bhakoo et al found 12.5% incidence in term and 55.5% in pre term babies born to febrile mothers. It has an independent association with neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

Predictive Values of Risk Factors in Neonatal Sepsis

Mk¹,

Mahmood²

2012

J. Bangladesh Coll. Phys.

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“…Ahmed et al 24 reported that more than half of the culture positive neonates were delivered at home (60%) and 7 [23%] culture positive babies were delivered by caesarean section. In the study of Knudsen et al, 25 the majority of the study population was poor and delivered at home, largely in the hands of untrained birth attendants. Home deliveries are significantly related to birth asphyxia, which was highly prevalent in population and which in turn is associated with an increased risk of serious neonatal infection.…”

Section: Sex-wise Distribution Of Culture Positive Casesmentioning

confidence: 98%

Microbiological Profile of Neonatal Septicaemia Along With an Overview of the Clinical Scenario

Rajhans¹,

Raut²,

More³

et al. 2018

jemds

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BACKGROUND Neonatal sepsis takes a big toll of neonatal deaths in developing countries. It is estimated that up to 20% of the neonates develop sepsis and approximately 1% die of sepsis related causes. In India, sepsis is one of the commonest causes of neonatal mortality contributing to 19% of all neonatal deaths. The present study was undertaken to study aerobic bacterial profile of neonatal septicaemia by automated blood culture systems. MATERIALS AND METHODS This observational study was conducted in the Microbiology Laboratory of a tertiary care centre over a period of one and a half years [January 2013 to June 2014]. Blood samples of neonates of both sexes were collected and processed. Detailed history recording and clinical examination was conducted on each patient and findings were recorded. RESULTS Total 157 blood samples, 99 [63.05%] from male and 58 [36.94%] from female patients were processed. Out of 157 blood samples, 70 i.e. 44.58% were flagged as positive by BacT/ ALERT 3D 60 system and 87 [55.41%] were negative. Within the neonatal age group, 52 [74.28%] neonates with positive blood cultures were of the age less than one week. Out of 70 culture positive cases 64 [91.42%] deliveries were conducted in the hospitals, rest 6 [8.57%] were home-based deliveries. Out of 70, 12 [17.14%] neonates were having history of febrile illness in the mother during gestation. And 17 [24.28%] neonates were found to have history of Prolonged Rupture of Membranes [PROM] during delivery. 43 [61.42%] of the 70 positive cases had not attained their gestational maturity. Out of 70 blood culture positive neonates, 44 [62.85%] were having early-onset sepsis. Rest 26 [37.14%] were suffering from late-onset sepsis. All 70 blood cultures were monobacterial. Out of 70 isolates, 35 [50%] isolates were Gram-positive cocci and 35 [50%] isolates were Gram-negative bacilli. Least susceptibility of E. coli isolates was observed to Cefepime [18.75%] and Ampicillin [12.50%]. CONCLUSION Culture positivity was found more in male neonates as compared to females. The male-to-female ratio being 1.69: 1. Highest blood culture positivity, i.e. 74.28% was found in neonates of age less than one week. 17.14% out of 70 babies with positive culture were having history of maternal pyrexia during gestation. 24.28% cases were found to have prolonged rupture of membranes during deliveries. 61.42% cases were preterm deliveries. 60% babies were having low birth weight. 62.85% cases were having early-onset sepsis and 37.14% were of late-onset sepsis.

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“…We 16 and others [12][13][14] have shown that intrauterine exposure to infection is associated with low Apgar scores and need for ventilatory support in the delivery room. In addition, low Apgar scores and low pH tended to be more frequent in children with CP whose blood, tested in the neonatal period, contained markers of autoimmune disorders or abnormalities of coagulation factors.…”

Section: Commentmentioning

confidence: 99%

“…[12][13][14][15][16] Therefore, we also examined other perinatal and postneonatal characteristics of children with disabling spastic CP. The purpose of this effort was to identify other conditions that might have influenced outcome in children who met the stated criteria.…”

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confidence: 99%