Septicaemia with deep venous thrombosis and necrotising pneumonia caused by acute community-acquired methicillin-resistant Staphylococcus aureus in an infant with a three-year follow-up: a case report

Lu, Mei; Fu, Meijiao; Zhang, Yanhong; Shen, Tong; Xie, Hui; Liu, Dengli

doi:10.1186/s12879-022-07166-z

Cited by 4 publications

(2 citation statements)

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“…Although the plasma D-dimers concentration in newborns may be physiologically higher than in adults, it is still one of the basic laboratory markers of TECs and is a starting point for further diagnostics and a valuable guide when making decisions about prophylactic and therapeutic procedures, especially in newborns burdened with risk factors [39,48,49].…”

Section: Discussionmentioning

confidence: 99%

“…In adults, the plasma D-dimers concentration at which thrombosis is unlikely, is considered to be <500 ng/ml [45][46][47]. In newborns, based on the results of the above-mentioned study and the authors own extensive clinical and laboratory experience, it is proposed to adopt the following reference ranges of plasma D-dimers concentration: <500 ng/mlnormal concentration, sufficient to exclude TECs, 500 ng/ml-4,000 ng/ml -concentration requiring the extension of diagnostics with additional laboratory and imaging tests, and detailed analysis of TECs risk factors; a concentration of >4,000 ng/ml indicates the presence of TECs and is an indication for pharmacological treatment [39,48,49].…”

Section: Reference Value Of D-dimers Concentration In Newbornsmentioning

confidence: 99%

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Thromboembolic complications in newborns – diagnostic value of D-dimers concentration and proposed outline of enoxaparin use

Wątroba¹,

Bryda²

2022

J Pre Clin Clin Res.

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Introduction and Objective. Among paediatric patients, thromboembolic complications (TECs) are most often observed in newborns, especially premature infants requiring intensive care and the use of central vascular accesses. Prognosis depends on the presence of comorbidities, maturity of the newborn, and the location and size of the thrombus. The basic laboratory test that allows for the exclusion of TECs is assessment of the plasma D-dimers concentration, the correct value of which sufficiently excludes the presence of TECs. Review methods. The review attempts to systematize existing knowledge on the plasma D-dimers concentration in newborns, and creates a scheme for using enoxaparin (EX), helpful in everyday clinical practice. Brief description of the state of knowledge. There are single studies devoted to assessing the plasma D-dimers concentration in newborns, but they agree that the concentration in normal healthy adults does not apply to newborns, regardless of the postmenstrual age (PMA), because the plasma D-dimers concentration found in newborns are significantly higher, despite the lack of clinical and ultrasound features of thrombosis and normal results of other parameters of the coagulation system. Increased plasma D-dimers concentration in newborns may be due to delayed renal clearance of D-dimers and to physiological mechanisms related to the closing of the venous duct (DV) and arterial duct (DA) in the newborn. Summary. Plasma D-dimers concentration is one of the basic laboratory markers of TECs, and is a starting point for further diagnostics and a valuable guide when making decisions about prophylactic and therapeutic procedures. The use of EX, as well as other LMWHs, is slowly becoming the treatment of choice in paediatric patients and is increasingly more often recommended in newborns.

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Section: Discussionmentioning

confidence: 99%