SeqPeelSort: a spike sorting algorithm for single sensillum recordings

Raiser, Georg

doi:10.21105/joss.00792

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…Data analysis. Spike sorting was performed with a custom spike sorting algorithm for single sensillum recordings [14]. All further data analysis was performed with custom Python scripts.…”

Section: Methodsmentioning

confidence: 99%

Ephaptic coupling between olfactory receptor neurons is sensitive to relative stimulus timing: Implications for odour source discrimination

Raiser,

Galizia,

Szyszka

2023

Preprint

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Insect olfactory receptor neurons (ORNs) are often co-localized within sensilla and exhibit non-synaptic reciprocal inhibition through ephaptic coupling. It has been postulated that this inhibition aids odour source discrimination, as synchronous arrival of different odour molecules (odorants) from a single source should increase ephaptic inhibition, whereas asynchronous arrival of odorants from different sources should decrease ephaptic inhibition. However, it was as yet unknown whether temporal arrival patterns of different odorants indeed modulate ephaptic inhibition, since past studies have focused on ephaptic inhibition of sustained ORN responses to prolonged and constant odour stimuli. However, most natural odour stimuli are not constant but rather transient and fluctuate as a result of dispersion in turbulent plumes in the air. To investigate the role of ephaptic inhibition in olfaction within turbulent environments, we recorded co-localized ORNs in the fruit flyDrosophila melanogasterexposed to dynamic odorant mixtures. We found that ephaptic inhibition does modulate transient ORN responses, and the strength of ephaptic inhibition decreases as the synchrony between arriving odorants decreases. These results support the hypothesis that ephaptic inhibition aids odour source discrimination.

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“…Data analysis. Spike sorting was performed with a custom spike sorting algorithm for single sensillum recordings [14]. All further data analysis was performed with custom Python scripts.…”

Section: Methodsmentioning

confidence: 99%

Ephaptic coupling between olfactory receptor neurons is sensitive to relative stimulus timing: Implications for odour source discrimination

Raiser,

Galizia,

Szyszka

2023

Preprint

Self Cite

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“…To address this, we have developed a novel spike sorting algorithm Single-SensillumSort (SSSort) that explicitly builds a model of how the temporal shape of each neuron's spikes changes as a function of its own firing rate, and then uses these models to assign the best matching unit for a given spike. SSSort is a generalization and extension of SeqPeelSort (Raiser, 2018) with respect to arbitrary spike shape changes, via forming an explicit model of how these changes depend on firing rate. In brief, SSSort first detects all spikes in a recording and extracts the waveform shape around a temporal window.…”

Section: Spike Sortingmentioning

confidence: 99%

Neuronal odor coding in the larval sensory cone of Anopheles coluzzii: Complex responses from a simple system

et al. 2021

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SUMMARY Anopheles mosquitoes are the sole vectors of malaria. Although adult females are directly responsible for disease transmission and accordingly have been extensively studied, the survival of pre-adult larval stages is vital. Mosquito larvae utilize a spectrum of chemosensory and other cues to navigate their aquatic habitats to avoid predators and search for food. Here we examine larval olfactory responses, in which the peripheral components are associated with the antennal sensory cone. Larval behavior and sensory cone responses to volatile stimuli in Anopheles coluzzii demonstrate the sensory cone is particularly tuned to alcohols, thiazoles, and heterocyclics, and these responses can be assigned to discrete groups of sensory cone neurons with distinctive profiles. These studies reveal that the anopheline larvae actively sample volatile odors above their aquatic habitats via a highly sophisticated olfactory system that is sensitive to a broad range of compounds with significant behavioral relevance.

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SeqPeelSort: a spike sorting algorithm for single sensillum recordings

Cited by 2 publications

References 2 publications

Ephaptic coupling between olfactory receptor neurons is sensitive to relative stimulus timing: Implications for odour source discrimination

Ephaptic coupling between olfactory receptor neurons is sensitive to relative stimulus timing: Implications for odour source discrimination

Neuronal odor coding in the larval sensory cone of Anopheles coluzzii: Complex responses from a simple system

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