Sequelae of Premature Birth in Young Adults

Hedderich, Dennis M.; Boeckh‐Behrens, Tobias; Bäuml, Josef; Menegaux, Aurore; Daamen, Marcel; Zimmer, Claus; Bartmann, Peter; Scheef, Lukas; Boecker, Henning; Wolke, Dieter; Sorg, Christian; Spiro, Judith

doi:10.1007/s00062-020-00901-6

Cited by 15 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous analyses of this dataset using structural MRI include investigations of cortical architecture 7,8,12 , white matter 15,27,28 , subcortical structures 9,10 , and incidental findings on routine brain MRI 76 .…”

Section: Methodsmentioning

confidence: 99%

Decreased amygdala volume in adults after premature birth

Schmitz‐Koep

Zimmermann

Menegaux

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

Premature-born infants have impaired amygdala structure, presumably due to increased stress levels of premature birth mediated by the amygdala. However, accounting for lifelong plasticity of amygdala, it is unclear whether such structural changes persist into adulthood. To address this problem, we stated the following questions: first, are whole amygdala volumes reduced in premature-born adults? And second, as adult anxiety traits are often increased after prematurity and linked with amygdala structure, are alterations in amygdala associated with adults’ anxiety traits after premature birth? We addressed these questions by automated amygdala segmentation of MRI volumes in 101 very premature-born adults (< 32 weeks of gestation and/or birth weight below 1500 g) and 108 full-term controls at 26 years of age of a prospectively and longitudinally collected cohort. We found significantly lower whole amygdala volumes in premature-born adults. While premature-born adults had significantly higher T score for avoidant personality reflecting increased social anxiety trait, this trait was not correlated with amygdala volume alterations. Results demonstrate reduced amygdala volumes in premature born adults. Data suggest lasting effects of prematurity on amygdala structure.

show abstract

Section: Methodsmentioning

confidence: 99%

Decreased amygdala volume in adults after premature birth

Schmitz‐Koep

Zimmermann

Menegaux

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the more subtle type, diffuse WMI, remains persistent [ 3 , 4 ]. Diffuse WMI leads to long-term neurodevelopmental and neurobehavioral impairments, resulting in severe cognitive and motor deficits until early adulthood [ 5 , 6 , 7 , 8 ]. The intellectual performance and overall well-being of WMI survivors are limited, leading to high economic and health burdens [ 1 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

All but Small: miRNAs from Wharton’s Jelly-Mesenchymal Stromal Cell Small Extracellular Vesicles Rescue Premature White Matter Injury after Intranasal Administration

Tscherrig,

Steinfort,

Haesler

et al. 2024

Cells

View full text Add to dashboard Cite

White matter injury (WMI) is a common neurological issue in premature-born neonates, often causing long-term disabilities. We recently demonstrated a key beneficial role of Wharton’s jelly mesenchymal stromal cell-derived small extracellular vesicles (WJ-MSC-sEVs) microRNAs (miRNAs) in WMI-related processes in vitro. Here, we studied the functions of WJ-MSC-sEV miRNAs in vivo using a preclinical rat model of premature WMI. Premature WMI was induced in rat pups through inflammation and hypoxia-ischemia. Small EVs were purified from the culture supernatant of human WJ-MSCs. The capacity of WJ-MSC-sEV-derived miRNAs to decrease microglia activation and promote oligodendrocyte maturation was evaluated by knocking down (k.d) DROSHA in WJ-MSCs, releasing sEVs containing significantly less mature miRNAs. Wharton’s jelly MSC-sEVs intranasally administrated 24 h upon injury reached the brain within 1 h, remained detectable for at least 24 h, significantly reduced microglial activation, and promoted oligodendrocyte maturation. The DROSHA k.d in WJ-MSCs lowered the therapeutic capabilities of sEVs in experimental premature WMI. Our results strongly indicate the relevance of miRNAs in the therapeutic abilities of WJ-MSC-sEVs in premature WMI in vivo, opening the path to clinical application.

show abstract

“…Beyond the cortex, enlarged ventricles have been reported in radiologic review ( Hedderich et al, 2021 ) and volumetric studies ( Cooke and Abernethy, 1999 ; Stewart et al, 1999 ; Nosarti et al, 2002 ; Kesler et al, 2004 ). Periventricular injury has been linked with neuronal loss in the thalamus and basal ganglia ( Volpe, 2009 ), and MRI studies have shown volumetric reductions in thalamus ( Nosarti et al, 2002 ; Lax et al, 2013 ; Brumbaugh et al, 2016 ; Sølsnes et al, 2016 ; Botellero et al, 2017 ; Sripada et al, 2018 ; Córcoles-Parada et al, 2019 ) and basal ganglia ( Nagy et al, 2009 ; Botellero et al, 2017 ; Karolis et al, 2017 ; Schmitz-Koep et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Long-Term Effects of Preterm Birth on Children’s Brain Structure: An Analysis of the Adolescent Brain Cognitive Development (ABCD) Study

Nath

Beltrano

Haynes

et al. 2023

eNeuro

View full text Add to dashboard Cite

Approximately 10% of births are preterm (PTB; <37 weeks gestational age; GA), which confers risk for cognitive, behavioral, and mental health challenges. Using the large and relatively diverse (i.e., designed to reflect sociodemographic variation in the US population) Adolescent Brain Cognitive DevelopmentSMStudy (ABCD Study®), we characterized the impact of PTB on brain structure in middle-late childhood (9-10 years). The ABCD sample covers the GA spectrum, and the large sample size (∼11,500) permits consideration of how associations between PTB and brain structure are impacted by GA, sex, birthweight, and analytic choices such as controlling for total brain size. We found a pattern of relative cortical thinning in temporoparietal and dorsal prefrontal regions and thickening of medial prefrontal and occipital regions in PTB compared to children born full term (≥37 weeks GA). This pattern was apparent when controlling for mean thickness and when considering moderate (>32 and <37 weeks GA) and very PTB (≤32 weeks GA) separately, relative to full term birth. Surface area and subcortical volumes showed reductions in PTB children that were largely attenuated when controlling for brain size. Effects on cortical thickness and surface area were partially mediated by birthweight. Although boys are at increased risk for adverse outcomes following PTB, there was limited evidence of sex differences of PTB effects. Finally, cortical thickness effects estimated in a ‘discovery’ sample (N=7528) predicted GA in a holdout ‘replication’ sample (N=2139). Our findings help to clarify the effects of PTB on brain structure into late childhood across the GA spectrum.SignificancePreterm birth (PTB) affects ∼10% of children and increases the risk of neurodevelopmental and mental health challenges. Here we examined long-term effects of PTB on brain structure in middle-late childhood in the large and relatively diverse ABCD sample. We further assessed the influence of gestational age, sex, birthweight, controlling for brain size and data quality. Our findings replicate a pattern of occipitotemporal and dorsal prefrontal cortical thinning in PTB that was seen in both moderate preterm and very preterm relative to full-term birth. Effects were similar in males and females and partially mediated by birthweight. Our findings suggest that community-recruited children born preterm show a pattern of structural alterations on a continuum that relates to gestational age and birthweight.

show abstract

Sequelae of Premature Birth in Young Adults

Cited by 15 publications

References 47 publications

Decreased amygdala volume in adults after premature birth

Decreased amygdala volume in adults after premature birth

All but Small: miRNAs from Wharton’s Jelly-Mesenchymal Stromal Cell Small Extracellular Vesicles Rescue Premature White Matter Injury after Intranasal Administration

Long-Term Effects of Preterm Birth on Children’s Brain Structure: An Analysis of the Adolescent Brain Cognitive Development (ABCD) Study

Contact Info

Product

Resources

About