Séquelles sensorielles, esthétiques et dentaires après traitement pour un cancer dans l’enfance

Thouvenin-Doulet, Sandrine; Fayoux, P.; Broucqsault, H.; Bernier-Chastagner, Valérie

doi:10.1016/j.bulcan.2015.04.006

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…Both patients had low salivary flow rates. This has been observed in previous studies [ 6 ]. Both of the patients’ mouth openings were normal.…”

Section: To the Editorsupporting

confidence: 89%

“…When pediatric patients are exposed to radiation during the period of tooth development, the formation of dental anomalies such as hypodontia, the cessation of root development, microdontia, taurodontism, temporomandibular joint disorders, malocclusion, and enamel hypoplasia can occur [ 4 , 5 , 6 , 7 , 8 ]. Such problems do not occur in adults.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

Late Side Effects of Chemotherapy and Radiotherapy in Early Childhood on the Teeth: Two Case Reports

Yılmaz

Bayrakdar

Bayrak

et al. 2018

Tjh

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“…Both patients had low salivary flow rates. This has been observed in previous studies [ 6 ]. Both of the patients’ mouth openings were normal.…”

Section: To the Editorsupporting

confidence: 89%

Section: To the Editormentioning

confidence: 99%

Late Side Effects of Chemotherapy and Radiotherapy in Early Childhood on the Teeth: Two Case Reports

Yılmaz

Bayrakdar

Bayrak

et al. 2018

Tjh

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“…No second cancers were observed after a median follow‐up of 9.3 years. However, the theoretical increase in risk with radiotherapy of growth sequelae and second cancer in these growing children/adolescents may become evident with longer follow‐up . Half of the R2 procedures occurred during clinically urgent initial surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Any event grade≥2, by common terminology criteria for adverse events (CTCAEv5.0), was collected . Acute complications were defined as any event occurring during or within three months after completing treatment; long‐term sequelae were defined as events that persisted for at least 5 years after treatment .…”

Section: Methodsmentioning

confidence: 99%

Ewing’s Sarcoma of the Head and Neck: Margins are not just for surgeons

et al. 2018

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Background, MethodsTo describe the characteristics, treatments (systemic/local), and outcome (oncological/functional) of French patients with head and neck Ewing's sarcomas (HNES) registered in the Euro‐Ewing 99 (EE99) database. Specific patient‐level data were reviewed retrospective.ResultsForty‐seven HNES patients in the EE99 database had a median age of 11 years, 89% had bone tumors (skull 55%, mandible 21%, maxilla 11%), 89% had small tumors (<200 mL), and they were rarely metastatic (9%). Local treatment was surgery radiotherapy (55%), exclusively surgery (28%), or radiotherapy (17%). Metastatic relapses occurred in five patients with high relapse risk factors (metastasis at diagnosis, poor histological response, large tumors). Local progression/relapses (LR) after exclusive radiotherapy occurred in three patients with persistent extra‐osseous residue and in four patients considered R0 margins (postchemotherapy surgery, without postoperative radiotherapy [PORT]), reclassified by pathological review as R1a. Pathological review reclassified 72% of R0 margins: 11/18 to R1a and 2/18 to R2. Five patients had confirmed R0 margins after postchemotherapy surgery without PORT and had no LR Eight patients had R2 margins (initial surgery without previous chemotherapy, with PORT) and had no LR With a median follow‐up of 9.3 years, the 3‐year LR rate, EFS, and OS were 84.8%, 78.6%, and 89.3%, respectively. Among the 5‐year survivors, 88% had long‐term sequelae.ConclusionTo optimize HNES management, patients should be treated from diagnosis in expert centers with multidisciplinary committees to discuss treatment strategy (type of surgery, need for PORT) and validate surgical margins.

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“…Although the absolute number of young patients undergoing radiation treatment is moderate, 1 the presence of malignancy in their developing bodies is likely to impact their entire life both physically and psychologically. [2][3][4][5][6][7] Moreover, children arguably are the most susceptible to adverse effects of radiation treatment and thus stand to benefit most from improvements in planning under the desired hypothesis of long-term survival, which is currently achieved for the treatment of Wilms' tumor, or nephroblastoma, the most common childhood abdominal malignancy. 8,9 For adult patients, many follow-up studies exist where the relationship between radiation treatment with specific dose (fractions) and onset of adverse effects is analyzed (see, e.g., the work of QUANTEC 10 ).…”

Section: Introductionmentioning

confidence: 99%

On the feasibility of automatically selecting similar patients in highly individualized radiotherapy dose reconstruction for historic data of pediatric cancer survivors

et al. 2018

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Purpose: The aim of this study is to establish the first step toward a novel and highly individualized three-dimensional (3D) dose distribution reconstruction method, based on CT scans and organ delineations of recently treated patients. Specifically, the feasibility of automatically selecting the CT scan of a recently treated childhood cancer patient who is similar to a given historically treated child who suffered from Wilms' tumor is assessed. Methods: A cohort of 37 recently treated children between 2-and 6-yr old are considered. Five potential notions of ground-truth similarity are proposed, each focusing on different anatomical aspects. These notions are automatically computed from CT scans of the abdomen and 3D organ delineations (liver, spleen, spinal cord, external body contour). The first is based on deformable image registration, the second on the Dice similarity coefficient, the third on the Hausdorff distance, the fourth on pairwise organ distances, and the last is computed by means of the overlap volume histogram. The relationship between typically available features of historically treated patients and the proposed ground-truth notions of similarity is studied by adopting state-of-the-art machine learning techniques, including random forest. Also, the feasibility of automatically selecting the most similar patient is assessed by comparing ground-truth rankings of similarity with predicted rankings. Results: Similarities (mainly) based on the external abdomen shape and on the pairwise organ distances are highly correlated (Pearson r p ≥ 0.70) and are successfully modeled with random forests based on historically recorded features (pseudo-R 2 ≥ 0.69). In contrast, similarities based on the shape of internal organs cannot be modeled. For the similarities that random forest can reliably model, an estimation of feature relevance indicates that abdominal diameters and weight are the most important. Experiments on automatically selecting similar patients lead to coarse, yet quite robust results: the most similar patient is retrieved only 22% of the times, however, the error in worst-case scenarios is limited, with the fourth most similar patient being retrieved. Conclusions: Results demonstrate that automatically selecting similar patients is feasible when focusing on the shape of the external abdomen and on the position of internal organs. Moreover, whereas the common practice in phantom-based dose reconstruction is to select a representative phantom using age, height, and weight as discriminant factors for any treatment scenario, our analysis on abdominal tumor treatment for children shows that the most relevant features are weight and the anterior-posterior and left-right abdominal diameters.

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Séquelles sensorielles, esthétiques et dentaires après traitement pour un cancer dans l’enfance

Cited by 7 publications

References 26 publications

Late Side Effects of Chemotherapy and Radiotherapy in Early Childhood on the Teeth: Two Case Reports

Late Side Effects of Chemotherapy and Radiotherapy in Early Childhood on the Teeth: Two Case Reports

Ewing’s Sarcoma of the Head and Neck: Margins are not just for surgeons

On the feasibility of automatically selecting similar patients in highly individualized radiotherapy dose reconstruction for historic data of pediatric cancer survivors

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