Sequence Analysis of the<i>UCP1</i>Gene in a Severe Obese Population from Southern Italy

Labruna, Giuseppe; Pasanisi, Fabrizio; Fortunato, Giuliana; Nardelli, Carmela; Finelli, Carmine; Farinaro, Eduardo; Contaldo, Franco; Sacchetti, Lucia

doi:10.1155/2011/269043

Cited by 14 publications

(3 citation statements)

References 23 publications

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“…Adaptive thermogenesis by uncoupling protein-1 (UCP1) could be a physiological defense against obesity ( 43 ). UCP1 expression is known to be a significant component of whole body energy expenditure, and its dysfunction contributes to the development of obesity ( 46 ). In fact, during normal metabolism, the body produces heat, a process also called thermogenesis, and fucoxanthin increases the amount of energy released as heat in fat tissue.…”

Section: Fucoxanthinmentioning

confidence: 99%

Carotenoids: potential allies of cardiovascular health?

Gammone

Riccioni

D’Orazio

2015

Food & Nutrition Research

218

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Carotenoids are a class of natural, fat-soluble pigments found principally in plants. They have potential antioxidant biological properties because of their chemical structure and interaction with biological membranes. Epidemiologic studies supported the hypothesis that antioxidants could be used as an inexpensive means of both primary and secondary cardiovascular disease (CVD) prevention. In fact, the oxidation of low-density lipoproteins (LDL) in the vessels plays a key role in the development of atherosclerotic lesions. The resistance of LDL to oxidation is increased by high dietary antioxidant intake, so that carotenoids, as part of food patterns such as the Mediterranean diet, may have beneficial effects on cardiovascular health too. Further properties of carotenoids leading to a potential reduction of cardiovascular risk are represented by lowering of blood pressure, reduction of pro-inflammatory cytokines and markers of inflammation (such as C-reactive protein), and improvement of insulin sensitivity in muscle, liver, and adipose tissues. In addition, recent nutrigenomics studies have focused on the exceptional ability of carotenoids in modulating the expression of specific genes involved in cell metabolism. The aim of this review is to focus attention to this effect of some carotenoids to prevent CVD.

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Section: Fucoxanthinmentioning

confidence: 99%

Carotenoids: potential allies of cardiovascular health?

Gammone

Riccioni

D’Orazio

2015

Food & Nutrition Research

218

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“…A total of 30 SNPs were found (see Table 2 ), suggesting that the ovine UCP1 is quite variable. In this regard, extensive heterogeneity has also been described in humans [ 17 , 20 ], rats [ 11 , 21 ], cattle [ 18 ], and chickens [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Sequence and Haplotypes Variation of the Ovine Uncoupling Protein-1 Gene (UCP1) and Their Association with Growth and Carcass Traits in New Zealand Romney Lambs

Zhou

et al. 2018

Genes

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Uncoupling protein-1 gene (UCP1) plays an important role in the regulation of thermogenesis, energy expenditure, and protection against oxidative stress. In this study, six separate UCP1 regions: region-1 and region-2 (two parts of the promoter), region-3 and region-4 (two parts of intron 1), region-5 (spanning part of intron 5 and part of exon 6), and region-6 (spanning part of exon 6 and part of the 3′-UTR) from a variety of sheep breeds, were analysed using polymerase chain reaction-single-stranded conformational polymorphism (PCR-SSCP) analyses. In total, 30 single nucleotide polymorphisms (SNPs) were detected. Of these, 14 were located in the promoter, eight were found in intron 1, six were found in intron 5, and one was found in the 3′-UTR. One substitution in exon 6 (c.910A/G) would putatively result in an amino acid change (p.Thr304Ala). Twenty-eight novel SNPs and nine new haplotypes spanning region-2 to region-5 were identified. Of these nine haplotypes, five were common (B2-A5, C2-A5, C2-C5, A2-A5, and A2-B5) and four were rare (C2-B5, A2-C5, B2-C5, and B2-B5) in the sheep investigated. Of the five common haplotypes found in 314 New Zealand Romney sheep for which growth and carcass trait data were available, the presence of A2-B5 was associated with decreased hot carcass weight (HCW) and loin lean-meat yield (p = 0.006, p = 0.032, respectively), and the presence of C2-C5 was associated with a decreased proportion of leg lean-meat yield (p = 0.047) in the carcasses. No associations were found with growth traits. These results confirm that ovine UCP1 is a variable gene and may have value as a genetic marker for sheep breeding.

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“…In this therapeutic context, it is important to mention that mutations in the UCP1 gene could be involved in the pathology of obesity. In this sense, some nucleotide substitutions in the UCP1 gene were described in obese people suggesting that specific variations of UCP1 could promote energy storage and contribute to the development of obesity [98]. Other specific UCP1 polymorphisms, such as rs1800592 and rs3811791, are associated with obesity and abnormal values of high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides levels [99].…”

Section: Thermogenesis a Therapeutic Treatment For Obesity?mentioning

confidence: 99%

Incendiary Leptin

et al. 2020

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Leptin is a hormone released by adipose tissue that plays a key role in the control of energy homeostasis through its binding to leptin receptors (LepR), mainly expressed in the hypothalamus. Most scientific evidence points to leptin’s satiating effect being due to its dual capacity to promote the expression of anorexigenic neuropeptides and to reduce orexigenic expression in the hypothalamus. However, it has also been demonstrated that leptin can stimulate (i) thermogenesis in brown adipose tissue (BAT) and (ii) the browning of white adipose tissue (WAT). Since the demonstration of the importance of BAT in humans 10 years ago, its study has aroused great interest, mainly in the improvement of obesity-associated metabolic disorders through the induction of thermogenesis. Consequently, several strategies targeting BAT activation (mainly in rodent models) have demonstrated great potential to improve hyperlipidemias, hepatic steatosis, insulin resistance and weight gain, leading to an overall healthier metabolic profile. Here, we review the potential therapeutic ability of leptin to correct obesity and other metabolic disorders, not only through its satiating effect, but by also utilizing its thermogenic properties.

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Sequence Analysis of theUCP1Gene in a Severe Obese Population from Southern Italy

Cited by 14 publications

References 23 publications

Carotenoids: potential allies of cardiovascular health?

Carotenoids: potential allies of cardiovascular health?

Sequence and Haplotypes Variation of the Ovine Uncoupling Protein-1 Gene (UCP1) and Their Association with Growth and Carcass Traits in New Zealand Romney Lambs

Incendiary Leptin

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