Sequence and analysis of a 26·9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae

Boyer, Jeanne; Michaux, Grégoire; Fairhead, Cécile; Gaillon, Laurent; Dujon, Bernard

doi:10.1002/(sici)1097-0061(199612)12:15<1575::aid-yea45>3.0.co;2-e

Cited by 9 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FPGS is a monofunctional protein in yeast and is encoded by a gene located on the chromosome XV. 108 In protozoa, the genes coding for HPPK and DHPS activities may differ from one species to another. However, the related proteins studied so far were always multifunctional, containing HPPK and DHPS activities in Plasmodium falciparum and Toxoplasma gondii 23,24 and DHNA, HPPK and DHPS activities in Pneumocystis carinii.…”

Section: Similar Genes From Other Organismsmentioning

confidence: 99%

Folic acid and folates: the feasibility for nutritional enhancement in plant foods

Scott¹,

Rébeillé²,

Fletcher³

2000

J. Sci. Food Agric.

View full text Add to dashboard Cite

In mammalian and plant cells the folates play a key role in the methylation cycle and in the DNA biosynthesis cycle (in the de novo biosynthesis of purines and pyrimidines). De®ciency of folate in the diet is likely to result in a reduction in the capacity to synthesise DNA and maintain the usual rate of cell division. This most evidently results in the production of anaemia from folate de®ciency due to a reduction in the biosynthesis of cells in the bone marrow. In addition it has been shown that high levels of plasma homocysteine occur which is an important risk factor in cardiovascular disease. Furthermore it has been shown that reduced maternal folate status is associated with the progressive increase in neural tube defects in infants. There is good evidence for folate de®ciency in a considerable number of the population in developed countries, even where folate supplementation of foods is practised, and for a level of intake in excess of the recommended dietary allowance. This paper reviews the principal routes of folate biosynthesis in plants and the potential for increasing the levels of natural folates through conventional plant breeding and biotechnological means. The effect of the major food preservation processes on the levels of folates in plants is also reviewed. The current information about the bioavailability of folates from plant food sources, and how this might be improved, is also summarised. The important health bene®ts that would arise from increasing folate intake in the diet provide a strong incentive for considering how this might be achieved.

show abstract

Section: Similar Genes From Other Organismsmentioning

confidence: 99%

Folic acid and folates: the feasibility for nutritional enhancement in plant foods

Scott¹,

Rébeillé²,

Fletcher³

2000

J. Sci. Food Agric.

View full text Add to dashboard Cite

show abstract

Folic acid and folates: the feasibility for nutritional enhancement in plant foods

Scott¹,

Rébeillé²,

Fletcher³

2000

J. Sci. Food Agric.

289

237

View full text Add to dashboard Cite

In mammalian and plant cells the folates play a key role in the methylation cycle and in the DNA biosynthesis cycle (in the de novo biosynthesis of purines and pyrimidines). Deficiency of folate in the diet is likely to result in a reduction in the capacity to synthesise DNA and maintain the usual rate of cell division. This most evidently results in the production of anaemia from folate deficiency due to a reduction in the biosynthesis of cells in the bone marrow. In addition it has been shown that high levels of plasma homocysteine occur which is an important risk factor in cardiovascular disease. Furthermore it has been shown that reduced maternal folate status is associated with the progressive increase in neural tube defects in infants. There is good evidence for folate deficiency in a considerable number of the population in developed countries, even where folate supplementation of foods is practised, and for a level of intake in excess of the recommended dietary allowance. This paper reviews the principal routes of folate biosynthesis in plants and the potential for increasing the levels of natural folates through conventional plant breeding and biotechnological means. The effect of the major food preservation processes on the levels of folates in plants is also reviewed. The current information about the bioavailability of folates from plant food sources, and how this might be improved, is also summarised. The important health benefits that would arise from increasing folate intake in the diet provide a strong incentive for considering how this might be achieved. © 2000 Society of Chemical Industry

show abstract

Disruption of Cytoplasmic and Mitochondrial Folylpolyglutamate Synthetase Activity in Saccharomyces cerevisiae

DeSouza

Shen

Bognar

2000

Archives of Biochemistry and Biophysics

View full text Add to dashboard Cite

Sequence and analysis of a 26·9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae

Cited by 9 publications

References 40 publications

Folic acid and folates: the feasibility for nutritional enhancement in plant foods

Folic acid and folates: the feasibility for nutritional enhancement in plant foods

Folic acid and folates: the feasibility for nutritional enhancement in plant foods

Disruption of Cytoplasmic and Mitochondrial Folylpolyglutamate Synthetase Activity in Saccharomyces cerevisiae

Contact Info

Product

Resources

About