Sequence-Based analysis of the HLA-DRB1 polymorphism in Metalsa Berber and Chaouya Arabic-speaking groups from Morocco

Oumhani, Khadija; Canossi, A.; Piancatelli, D.; Rocco, M. Di; Beato, Tiziana Del; Liberatore, G.; Aureli, Anna; Jouad, Abd Elaziz Ben; Aouad, Rajae El; Adorno, D.; Casciani, Carlo Umberto

doi:10.1016/s0198-8859(01)00370-6

Cited by 27 publications

(28 citation statements)

References 20 publications

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“…The great affinity that exists between the Arab and Berber Algerian populations and the other North African populations is consistent with the findings obtained using other genetic markers (Blood groups: Flores et al, 2000a;SanchezMazas, 2000;Harich et al, 2002;Gm: Loueslati et al, 2001;Dugoujon et al, 2004;HLA: Bosch et al, 1997;Gómez-Casado et al, 2000;Arnaiz-Villena et al, 2002;Choukri et al, 2002;Ouhmani et al, 2002;Y chromosome: Bosch et al, 2001;Khodjet El Khil et al, 2001; Alu sequences: Flores et al, 2000b). It is, therefore, legitimate to suppose that great genetic, geographical, linguistic, and cultural similarities have developed between these populations.…”

Section: Resultssupporting

confidence: 88%

A genetic study of nine populations from the region of Tlemcen in Western Algeria: a comparative analysis on the Mediterranean scale

Metri

Sidi-Yakhlef

Biémont

et al. 2012

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We characterized 2005 individuals from nine populations in the region of Tlemcen in Western Algeria for the ABO, rhesus, MNSs, and Duffy blood groups, in association with genetic traits. The results were compared to those for other populations in Algeria, North Africa, and Southern Europe, in order to situate and clarify the genetic status of this region. Principal-component analyses and phylogenetic trees of the matrices of the genetic distances, on the regional and Mediterranean scales, reveal strong homogeneity at the regional level and convergence between North African populations. This indicates high genetic affinities among these populations. This study highlights the differences between the two sides of the Mediterranean, probably due to the independent peopling history of these populations after they had settled. The resulting genetic structure of these populations is best explained by a combination of gene flow, ecology, and history.

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Section: Resultssupporting

confidence: 88%

A genetic study of nine populations from the region of Tlemcen in Western Algeria: a comparative analysis on the Mediterranean scale

Metri

Sidi-Yakhlef

Biémont

et al. 2012

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“…Distribution of alleles and haplotypes observed in our controls are in accordance with previous Moroccan studies (Brick et al, 2006;Oumhani et al, 2002;Canosi at al., 2010). Our data confirm the well-known positive association between T1D and HLA-DRB1*03 and -DRB*04.…”

Section: Discussionsupporting

confidence: 92%

Human leukocyte antigen (HLA) polymorphism and type 1 diabetes in the Moroccan population

Benseffaj¹,

Brick²,

Atouf³

et al. 2012

Afr. J. Biotechnol.

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Insulin-dependent diabetes mellitus or type 1 diabetes is an autoimmune multifactorial disease which has a great socio-economic impact. In Morocco, less is known about the contribution of Human leukocyte antigen (HLA) alleles to type 1 diabetes susceptibility. Our study focused on evaluating the distribution of class II HLA genes among Moroccan patients presenting type 1 diabetes coming from different regions of the country. A total of 76 patients diagnosed with type I diabetes were compared to a group of 248 healthy controls matched by age, sex, and ethnic origin. The HLA class II (DR and DQ) typing of patients and controls was performed using polymerase chain reaction sequence-specific primers (PCR-SSP). Ambiguous typings were reanalyzed by Luminex technology. We found a significant association between HLA-DRB1*03 (p = 0.0001), DRB1*04 (p = 0.0001), DQB1*02 (p = 0.0001, OR = 4.4) and DQB1*03 (p = 0.002) alleles frequencies and the susceptibility to diabetes. The HLA-DQB1*06 allele was significantly decreased in patients (p = 0.008). DRB1*03-DQB1*02, DRB1*04-DQB1*03 and DRB1*04-DQB1*02 haplotypes induce susceptibility to type 1 diabetes while DRB1*13-DQB1*06 and DRB1*15-DQB1*06 haplotypes seems to confer a protective effect in our population. These data highlights that Moroccans diabetic patients do share a series of traits with diabetics of other origins but also have specific characteristics.

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“…Three haplotypes (DRB1*0701-DQA1*0201-DQB1*0201, DRB1*0301-DQA1*0501-DQB1*0201 and DRB1*11-DQA1*0501-DQB1*0301) are accounted for nearly 50% of the total gene frequencies. Many other studies on HLA typing of Moroccan population have confirmed the above mentioned high frequency types in the Moroccan population [7][8][9][10]. On the other hand, it is also well established that IgG antibodies against HLA-I and -II molecules do occur naturally as auto-or allo-antibodies in non-alloimmunized males [11 -20].…”

Section: Introductionmentioning

confidence: 77%

Characterization of the Anti-HLA Class I and II IgG Antibodies in Moroccan IVIg Using Regular Beads and Ibeads in Luminex Multiplex Single Antigen Immunoassay

Hilali¹

2017

IJI

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Sequence-Based analysis of the HLA-DRB1 polymorphism in Metalsa Berber and Chaouya Arabic-speaking groups from Morocco

Cited by 27 publications

References 20 publications

A genetic study of nine populations from the region of Tlemcen in Western Algeria: a comparative analysis on the Mediterranean scale

A genetic study of nine populations from the region of Tlemcen in Western Algeria: a comparative analysis on the Mediterranean scale

Human leukocyte antigen (HLA) polymorphism and type 1 diabetes in the Moroccan population

Characterization of the Anti-HLA Class I and II IgG Antibodies in Moroccan IVIg Using Regular Beads and Ibeads in Luminex Multiplex Single Antigen Immunoassay

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