Sequence information transfer using covalent template-directed synthesis

Núñez‐Villanueva, Diego; Ciaccia, Maria; Iadevaia, Giulia; Sanna, Elena; Hunter, Christopher A.

doi:10.1039/c9sc01460h

Cited by 40 publications

(79 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although rudimentary self‐replication behaviors have been demonstrated, most of the reported systems do not allow transfer of coded information sequences as achieved by nucleic acids . In these context, there was earlier this year two interesting examples of sequence information transfer using dynamic (Figure ) or covalent bonds between coded template and substrates. Yet, these examples were achieved with rather small information sequences ( i. e .…”

Section: Synthetic Chemistrymentioning

confidence: 99%

Can Life Emerge from Synthetic Polymers?

Lutz

2019

Israel Journal of Chemistry

View full text Add to dashboard Cite

Synthetic chemistry has drastically progressed during the last few decades. Like in DNA, it is now possible to synthesize abiotic macromolecules with precisely‐controlled sequences of monomers. Artificial systems allowing hybridization and information transfer have been described. Simple metabolism models have also been prepared and investigated. Thus, the creation of minimal artificial life forms appears as a (still relatively far) but possibly reachable objective. In this context, the aim of the present essay is to discuss recent achievement and future challenges towards man‐induced abiogenesis. In terms of polymer design, a synthetic macromolecule that would support Life as DNA do would require at least all the following properties: (i) information‐storage capacity, (ii) information‐transfer ability and (iii) the possibility to evolve through molecular mutations. Recent advances in that direction are summarized herein. However, Life is not only a matter of macromolecular design. In order to operate, a self‐replicator shall co‐exist with other molecules in non‐equilibrium conditions. Hence, systems chemistry aspects are also discussed in this essay.

show abstract

Section: Synthetic Chemistrymentioning

confidence: 99%

Can Life Emerge from Synthetic Polymers?

Lutz

2019

Israel Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…4,5 Indeed, some very significant progress in devising a synthetic "information chemistry" has been made in recent years, notably with the development of sequence-specific polymerisation (i.e. sequence-writing) methodologies and mass-spectrometric sequencing techniques, [6][7][8] information-transfer protocols, [9][10][11] and the use of small "reader-molecules" to recognise and report copolymer sequence-information. [12][13][14][15] Using the latter technique, we recently showed that highly sequence-dependent 1 H NMR complexation shifts are produced in the spectra of copolyimides based on 1,4,5,8-naphthalene tetracarboxylic diimide (NDI) on complexation of an aromatic "probe" molecule such as pyrene or perylene.…”

Section: Introductionmentioning

confidence: 99%

Single-Site Binding of Pyrene to Poly(ester-Imide)s Incorporating Long Spacer Units: Prediction of NMR Resonance-Patterns from a Fractal Model

Knappert¹,

Jin²,

Midgley³

et al. 2020

Preprint

View full text Add to dashboard Cite

Co-polycondensation of the diimide-based diols N,N'-bis(2-hydroxyethyl)hexafluoro-isopropylidene-diphthalimide, (HFDI), and N,N'-bis(2-hydroxy-ethyl)naphthalene-1,4,5,8-tetracarboxylic-diimide, (NDI), with aliphatic diacyl chlorides ClOC(CH2)xCOCl (x = 5 to 8) affords linear copoly(ester-imide)s. Such copolymers interact with pyrene via supramolecular binding of the polycyclic aromatic molecule at NDI residues. This results in upfield complexation shifts and sequence-related splittings of the NDI 1H NMR resonances, but gives a very different resonance-pattern from the corresponding copolymer where x = 2. Computational modelling of the polymer with x = 5 suggests that, in this system, each pyrene molecule binds to just a single NDI residue rather than to an adjacent pair of NDI's in a tight chain-fold ("dual-site" binding) as found for x = 2. The new single-site binding model enables the pattern of 1H NMR resonances for copolymers with longer spacers (x = 5 to 8) to be reproduced and assigned by simulation from sequence-specific shielding factors based on the fractal known as the fourth-quarter Cantor set. As this set also enables an understanding of dual-site binding systems, it evidently provides a general numerical framework for supramolecular sequence-analysis in binary copolymers.

show abstract

“…4,5 Indeed, some very significant progress in devising a synthetic "information chemistry" has been made in recent years, notably with the development of sequence-specic polymerisation (i.e. sequence-writing) methodologies and mass-spectrometric sequencing techniques, [6][7][8] information-transfer protocols, [9][10][11] and the use of small "readermolecules" to recognise and report copolymer sequenceinformation. [12][13][14][15] Using the latter technique, we recently showed that highly sequence-dependent 1 H NMR complexation shis are produced in the spectra of copolyimides based on 1,4,5,8-naphthalene tetracarboxylic diimide (NDI) on complexation of an aromatic "probe" molecule such as pyrene or perylene.…”

Section: Introductionmentioning

confidence: 99%