Sequence of the NS 1 gene of the K 23 isolate of tick-borne encephalitis virus and identification of conserved motifs

Jacobs, Sydney; Stephenson, J R; Wilkinson, Gavin William Grahame

doi:10.1007/bf01316902

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…The high levels of cross-protection observed here are consistent with the sequence and structural conservation previously reported for the NS1 protein of some of the viruses from the TBEV complex (Jacobs et al, 1993), although NS1 gene sequences of several of the TBEV strains used in this study are not currently available.…”

Section: Discussionsupporting

confidence: 90%

Immunological basis for protection in a murine model of tick-borne encephalitis by a recombinant adenovirus carrying the gene encoding the NS1 non-structural protein.

Timofeev

Ozherelkov

Пронин

et al. 1998

Journal of General Virology

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The humoral immune response to flaviviruses is mainly directed to the major envelope protein, E, and a glycosylated non-structural protein, NS1. Cellmediated immune responses, however, appear to be directed mainly against non-structural proteins. Experiments described here show that a defective recombinant adenovirus (Rad51) containing the gene encoding the NS1 protein of tick-borne encephalitis virus can induce a strong protective immune response against several pathogenic tickborne flaviviruses in an experimental animal model, and can enhance the efficacy of conventional vaccine

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Section: Discussionsupporting

confidence: 90%

Immunological basis for protection in a murine model of tick-borne encephalitis by a recombinant adenovirus carrying the gene encoding the NS1 non-structural protein.

Timofeev

Ozherelkov

Пронин

et al. 1998

Journal of General Virology

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“…Knowledge of TBEV characteristics in Sweden is limited and there is only one patient isolate reported previously [von Zeipel, 1959]. A high degree of homology between vaccine strains used in Europe (Neudoerfl and K23) and a few European isolates has been reported [Jacobs et al, 1993;Ecker et al, 1999]. Thus, an efficient protection against Swedish TBEV strains may also be anticipated, but no data have so far been available.…”

Section: Discussionmentioning

confidence: 99%

Characterisation of human tick‐borne encephalitis virus from Sweden

Haglund

Vene

Forsgren

et al. 2003

Journal of Medical Virology

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Viruses of the tick-borne encephalitis (TBE) antigenic complex, within the family Flaviviridae, cause a variety of diseases including uncomplicated febrile illness, meningo-encephalitis and haemorrhagic fever. Different wildlife species act as reservoir hosts with ixodid tick species as vectors. TBE virus (TBEV) causes 40-130 cases confirmed serologically in Sweden each year. Characteristics of TBEV strains circulating in Sweden have not been investigated previously and no viral sequence data has been reported. In the present study, virus strains were isolated from serum of patients with clinical symptoms consistent with acute TBEV infection. Serologic characterisation, using a panel of E-specific monoclonal antibodies and cross-neutralisation tests, indicated that the Swedish strains of TBEV, isolated 1958-1994, all belonged to the Western TBEV subtype, which includes the Austrian vaccine strain Neudoerfl. Genetic analysis of a partial E-sequence confirmed this close relationship: all Swedish TBEV strains belonged to the European lineage of the Western TBEV subtype, which includes the previously characterised strains Neudoerfl, Hypr, and Kumlinge. Further, three Swedish strains showed partial E-sequences identical to that of the Finnish Kumlinge strain, ten Swedish strains formed a well-supported separate cluster, whereas four others did not show any real clustering. No apparent correlation was observed in comparison of clinical parameters with genetic data or geographic origin of the strains.

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Viral zoonosis from the viewpoint of their epidemiological surveillance: tick-borne encephalitis as a model

Süß

Béziat

Schrader

1997

Viral Zoonoses and Food of Animal Origin

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Sequence of the NS 1 gene of the K 23 isolate of tick-borne encephalitis virus and identification of conserved motifs

Abstract: The NS 1 gene from the K 23 isolate of tick-borne encephalitis virus has been sequenced. The NS 1 gene sequence, and many structural features of the NS 1 protein are heavily conserved. Six conserved peptides were also identified.

Cited by 5 publications

References 11 publications

Immunological basis for protection in a murine model of tick-borne encephalitis by a recombinant adenovirus carrying the gene encoding the NS1 non-structural protein.

Immunological basis for protection in a murine model of tick-borne encephalitis by a recombinant adenovirus carrying the gene encoding the NS1 non-structural protein.

Characterisation of human tick‐borne encephalitis virus from Sweden

Viral zoonosis from the viewpoint of their epidemiological surveillance: tick-borne encephalitis as a model

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