Sequence similarity between human immunodeficiency virus type 1 envelope protein (gp120) and human proteins: a new hypothesis on protective antibody production

Veljković, Veljko; Metlaš, R.

doi:10.1016/0165-2478(90)90145-g

Cited by 20 publications

(6 citation statements)

References 11 publications

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“…In two different parts of this sequence, a high degree of homology exists to Sequence Homology between HIV-1 and Antigen Receptor Molecules A computer analysis, in which we compared amino acid sequences of the envelope proteins gpl20, gp41, and gag proteins of HIV-1 with Ig and TCR molecules revealed many shared amino acid motifs. Table 1 summarizes our findings and those of other investigators [16][17][18]. Nearly the entire gpl60 protein sequence contains motifs that are homologous with antigen receptor molecules.…”

supporting

confidence: 58%

“…Affinity-puri fied anti-F(ab')2 antibodies of AIDS patients react against both Fab, gpl20, and uninfected CD4+ T cells that are precoated with recombinant gpl20 or preactivated with phytohemagglutinin [15]. The reactivity against gpl20 is not surprising since there are sequence homologies be tween gpl20 and variable and constant regions of IgG-Fab [16][17][18]. We were able to show that the anti-F(ab')2 activity in sera of HIV-infected patients is at least partly due to cross-reaction of anti-gpl20 antibodies with a homologous sequence in the constant CHI region of the IgG molecule [13].…”

mentioning

confidence: 99%

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Molecular Mimicry between HIV-1 and Antigen Receptor Molecules: A Clue to the Pathogenesis of AIDS

Süsal¹,

Kröpelin²,

Daniel³

et al. 1993

Vox Sanguinis

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There is increasing evidence that autoimmune phenomena play an important role in the immunopathogenesis of AIDS. We found a high degree of sequence homology between HIV-1 and antigen receptor molecules, immunoglobulins and T cell receptors. Based on recent findings that the appearance of anti-Fab autoantibodies and attachment of gp120/immunoglobulin/complement complexes on CD4+ T cells are associated with the decrease of CD4+ T cells in HIV-infected patients, we hypothesize herein that cross-reactive anti-F (ab')2 autoantibodies and circulating gp120 molecules are responsible for a destabilization of the immune network and the elimination of CD4+ T cells.

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supporting

confidence: 58%

mentioning

confidence: 99%

Molecular Mimicry between HIV-1 and Antigen Receptor Molecules: A Clue to the Pathogenesis of AIDS

Süsal¹,

Kröpelin²,

Daniel³

et al. 1993

Vox Sanguinis

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“…We reported the existence of immunoglobulin- [19,21,30]. This region reacts with antibodies of both normal and HIV-1 infected sera.…”

Section: Introductionmentioning

confidence: 92%

Anti-IgG Antibodies from Sera of Healthy Individuals Neutralize HIV-1 Primary Isolates.

Metlas¹,

Srdic²,

Veljković³

2007

CHR

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Immunoglobulins (Ig) of pooled healthy human sera were purified by affinity chromatography based on their reactivity with human IgG. This Ig fraction represent connected, natural antibodies (NAbs) and here are denoted as anti-IgG antibodies. The data revealed that IgG, IgA and IgM isotypes are constituents of anti-IgG fraction. The ability of anti-IgG antibodies to prevent infection of PBMC by HIV-1 was demonstrated. They exhibited different neutralizing activity depending on the phenotype of the tested virus. The efficacy of neutralization was comparable to monoclonal antibodies (MAbs) IgG1b12 at least for the HIV-1 (92HT593B) strain. These studies suggest that connected antibodies thus, constituents of immune network, could prevent infection by HIV-1. NAbs as essential components of therapeutic molecules of intravenous Ig (IVIg) have a beneficial effect on variety of immunological disorders by affecting the structure, function and dynamics of the immune network. Since, hallmark of HIV-1 infection are immunological disorders we hypothesizes that they might be corrected to some extend by anti-IgG antibodies.

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“…Despite the presence of the strongest T‐cell epitope of gp120, which is active in vitro (3–7) and an exposed B‐cell epitope (8,9), the C‐terminus of the C2 region encompassing amino acids 280–306 is not immunogenic in humans (3,10–12). Absence of the active B‐cell epitope within this peptide indicates that antibodies in sera of HIV patients recognizing this region of HIV‐1 gp120 represent autoreactive antibodies elicited by some human antigen.…”

Section: Introductionmentioning

confidence: 99%

Design of peptide mimetics of HIV‐1 gp120 for prevention and therapy of HIV disease

Veljković¹,

Branch²,

Metlaš³

et al. 2003

The Journal of Peptide Research

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It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Based on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease.

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Sequence similarity between human immunodeficiency virus type 1 envelope protein (gp120) and human proteins: a new hypothesis on protective antibody production

Cited by 20 publications

References 11 publications

Molecular Mimicry between HIV-1 and Antigen Receptor Molecules: A Clue to the Pathogenesis of AIDS

Molecular Mimicry between HIV-1 and Antigen Receptor Molecules: A Clue to the Pathogenesis of AIDS

Anti-IgG Antibodies from Sera of Healthy Individuals Neutralize HIV-1 Primary Isolates.

Design of peptide mimetics of HIV‐1 gp120 for prevention and therapy of HIV disease

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