Sequence-specific modification of DNA fragments by oligonucleotide derivatives containing alkylating groups at the C5 position of deoxyuridine.

Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide

“…A diverse array of non-natural nucleosides have been developed for cross-linking purposes with natural DNA/RNA targets. [3][4][5][6][7][8][9] However most of these methods require the introduction of modified bases and/or extensive additional protection/deprotection schemes.…”