2007
DOI: 10.1016/j.freeradbiomed.2007.08.027
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Sequence-specific oxidative base modifications in hypoxia-inducible genes

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Cited by 51 publications
(62 citation statements)
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“…By depleting RISP, the formation of ubisemiquinone at the Qo site is prevented, thus mimicking the response to myxothiazol. Taken together, these results are also consistent with a broader body of work indicating that hypoxia increases mitochondrial ROS signaling (10,17,18,(27)(28)(29)(36)(37)(38)(39).…”
Section: Discussionsupporting
confidence: 89%
“…By depleting RISP, the formation of ubisemiquinone at the Qo site is prevented, thus mimicking the response to myxothiazol. Taken together, these results are also consistent with a broader body of work indicating that hypoxia increases mitochondrial ROS signaling (10,17,18,(27)(28)(29)(36)(37)(38)(39).…”
Section: Discussionsupporting
confidence: 89%
“…Because HIF-1a protein is a major transcriptional controller of VEGF expression, and oxidative stress has been widely documented in human emphysematous lungs [38] and animal models of emphysema [39,40], we reason that oxidative stress, directly or indirectly affects HIF-1a protein expression. Of associated interest is the finding that in COPD lungs both VEGF [10] and HIF-1a protein expression is reduced in pulmonary arterial endothelial cells and pulmonary septal cells (fig.…”
Section: Discussionmentioning
confidence: 99%
“…Immediately after perfusion, lungs were snap frozen in liquid nitrogen and saved for determination of mtDNA content and oxidative mtDNA damage, global nuclear DNA damage, as well as oxidative damage to the indicated sequences of selected nuclear genes. Total DNA was isolated from lung samples powdered with a mortar and pestle, by previously described methods (19,26). Purified DNA samples were digested with PpuMI and AhdI restriction enzymes (New England Biolabs, Beverly, MA) and used for further analyses.…”
Section: Methodsmentioning
confidence: 99%