2022
DOI: 10.3390/app12073677
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Sequence-Specific Recognition of Double-Stranded DNA by Peptide Nucleic Acid Forming Double-Duplex Invasion Complex

Abstract: Peptide nucleic acid (PNA) is an analog of natural nucleic acids, where the sugar-phosphate backbone of DNA is replaced by an electrostatically neutral N-(2-aminoethyl)glycine backbone. This unique peptide-based backbone enables PNAs to form a very stable duplex with the complementary nucleic acids via Watson–Crick base pairing since there is no electrostatic repulsion between PNA and DNA·RNA. With this high nucleic acid affinity, PNAs have been used in a wide range of fields, from biological applications such… Show more

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Cited by 8 publications
(4 citation statements)
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“…DNA molecules with one or more mismatched pairs are called heteroduplexes; completely paired DNA molecules are known as homoduplexes. Aiba et al 80 studied the schematic interaction of these recognition principles. This efficient bonding of PNA/DNA creates a robust double-stranded complex that can withstand thermal stability.…”
Section: Selection Modification and Synthesis Of Peptidementioning
confidence: 99%
See 1 more Smart Citation
“…DNA molecules with one or more mismatched pairs are called heteroduplexes; completely paired DNA molecules are known as homoduplexes. Aiba et al 80 studied the schematic interaction of these recognition principles. This efficient bonding of PNA/DNA creates a robust double-stranded complex that can withstand thermal stability.…”
Section: Selection Modification and Synthesis Of Peptidementioning
confidence: 99%
“…DNA molecules with one or more mismatched pairs are called heteroduplexes; completely paired DNA molecules are known as homoduplexes. Aiba et al . studied the schematic interaction of these recognition principles.…”
Section: Selection Modification and Synthesis Of Peptidementioning
confidence: 99%
“…These challenges spurred the development of strand-invading strategies, i.e., probes capable of unzipping the Watson-Crick base-pairs of dsDNA targets and forming new, more stable Watson-Crick base-pairs between probe strands and the complementary DNA (cDNA) regions. Examples include various modified single-stranded PNAs, [8][9][10][11][12][13] as well as doublestranded probes like pseudo-complementary PNAs, [14][15][16][17][18] Invader probes, 19 heteroduplexes between intercalator-modified oligonucleotides and RNA, PNA or locked nucleic acid (LNA) strands, [20][21][22] and related approaches. [23][24][25][26] Some of these strand-invading strategies are discussed in more detail below.…”
Section: Introductionmentioning
confidence: 99%
“…A key advantage of strand-invading strategies is the prospect of the sequenceunrestricted recognition of dsDNA. Progress towards this end has been realized with various modified single-stranded PNAs [7][8][9][10][11][12], double-stranded probes such as pseudocomplementary (pc) PNAs [13][14][15], and related approaches [16][17][18][19][20][21][22][23].…”
Section: Introductionmentioning
confidence: 99%