2000
DOI: 10.1002/1531-8249(200008)48:2<164::aid-ana5>3.0.co;2-b
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Sequence specificity of aminoglycoside-induced stop codon readthrough: Potential implications for treatment of Duchenne muscular dystrophy

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Cited by 225 publications
(181 citation statements)
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“…This was consistent with the relative termination efficiency previously described for the three stop codons (UAA4UAG4UGA). 14,15 This hierarchy was also observed in the presence of 600 mg/ ml of gentamicin, UGA and UAG, with readthrough levels of 0.53 and 0.22%, respectively, and UAA only 0.076%. Nevertheless, in the presence or absence of gentamicin, this order might be completely changed due to the influence of the embedded stop condon context.…”
Section: Effect Of Stop Codon Identitymentioning
confidence: 74%
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“…This was consistent with the relative termination efficiency previously described for the three stop codons (UAA4UAG4UGA). 14,15 This hierarchy was also observed in the presence of 600 mg/ ml of gentamicin, UGA and UAG, with readthrough levels of 0.53 and 0.22%, respectively, and UAA only 0.076%. Nevertheless, in the presence or absence of gentamicin, this order might be completely changed due to the influence of the embedded stop condon context.…”
Section: Effect Of Stop Codon Identitymentioning
confidence: 74%
“…UAG gave more erratic results, with U or C being associated with high or low readthrough, possibly reflecting the difference in the surrounding context between the experimental systems used. 14,15 The contribution of the þ 4 nucleotide to gentamicin-induced readthrough appeared moderate in our collection of mutations. In particular, a C at this position could be associated with some of the highest readthrough levels, but also with very moderate ones.…”
Section: Effect Of the þ 4 Nucleotidementioning
confidence: 82%
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