Sequencing‐based analysis of the HLA‐DPB1 polymorphism in Nu ethnic group of south‐west China

Hu, Weihong; Wang, J.; Wang, B.; Lü, Jing; Li, H.; Zhang, J.; Cun, Yina; Tang, Wenru; Xiao, Chunjie

doi:10.1111/j.1744-313x.2006.00638.x

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…The majority of studies have shown that DPB1 locus is not under balancing selection. The present study showed that homozygosity for DPB1 locus does not differ significantly from the value expected under neutrality, which is in concordance with other previously published results (19).…”

Section: Introductionsupporting

confidence: 94%

HLA‐DPB1 polymorphism in Blang and Puyi ethnic groups of Southwest China inferred from sequence‐based typing

Wang

et al. 2007

Tissue Antigens

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In the present study, DNA typing for HLA-DPB1 was performed using polymerase chain reaction (PCR)-sequence-based typing method in two isolated Chinese populations: the Blangs (n = 94) in Shuangjiang County and the Puyis (n = 76) in Luoping County from Yunnan province of Southwest China. These two populations exhibited certain similarity in their allelic distributions of the HLA-DPB1 gene. A total of 11 and 12 alleles at the DPB1 locus were found in the Blang and Puyi groups, respectively. In the Blang group, the most frequent alleles were DPB1*0501 (51.0%) and DPB1*1301 (17.0%). DPB1*030101 was also common with a frequency of 6.4%. In the Puyi group, the most frequent allele was also DPB1*0501 with a frequency of 47.5%, followed by DPB1*1301 (21.1%). Two alleles DPB1*2101 and DPB1*0202 followed, with frequencies ranging between 5% and 8%. The alleles DPB1*4101, DPB1*3301, DPB1*6801 and DPB1*8401 were found for the first time in Chinese populations. A dendrogram constructed by neighbor-joining method showed that the Blang and Puyi ethnic minorities, which had the closest relationship belonged to the southern Chinese.

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Section: Introductionsupporting

confidence: 94%

HLA‐DPB1 polymorphism in Blang and Puyi ethnic groups of Southwest China inferred from sequence‐based typing

Wang

et al. 2007

Tissue Antigens

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“…DPB1*1301, the second frequent allele in Bais (13.28%), was also very common among many Southeast Asian populations. Likewise, the frequency of the DPB1*1301 in Chinese populations is also higher in southern Chinese populations (10.1%–33.3%) (13–17, 24–29) than in northern Chinese populations like Kazak (1.2%) (19), Shenyang Han (1.8%) (18), Man (2.1%) (20), Uygur (4.4%) (22) and Northern Han (5.1%) (21). DPB1*020101 and DPB1*040101, being the two widely observed alleles all over the world, were also frequently observed in Bai, with frequencies of 10.93% and 9.77%, respectively.…”

Section: Allele Frequencies Of Hla‐drb1 ‐Dqb1 and ‐Dpb1 In The Bai Ementioning

confidence: 93%

Polymorphism of HLA‐DRB1, ‐DQB1 and ‐DPB1 genes in Bai ethnic group in southwestern China

Hu¹,

Tang²,

Wang³

et al. 2008

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In this work, polymorphism of human leukocyte antigen (HLA)-DRB1, -DQB1 and -DPB1 genes was detected using polymerase chain reaction-sequence-based typing method in 128 healthy unrelated volunteers from the Bai ethnic group of Yunnan province of southwest China. Among all the 28 alleles detected for the DRB1 gene, the most common allele was DRB1*120201 with a frequency of 16.41%, followed by DRB1*090102, DRB1*080302, DRB1*1404, DRB1*150101, DRB1*140101 and DRB1*160201, with frequencies of 10.16%, 9.77%, 9.38%, 8.98%, 8.59% and 8.21%, respectively. Among 19 DQB1 alleles detected, the most frequent allele was DQB1*030101/0309 (35.94%), followed by DQB1*050201 (11.33%), DQB1*060101/060103 (10.54%) and DQB1*0401 (10.16%). For the DPB1 locus, the most common alleles were DPB1*0501 (42.19%), DPB1*1301 (13.28%), DPB1*020102 (10.93%) and DPB1*040101 (9.77%). The comparison of HLA class II allele frequencies of Bais with those of other Chinese populations suggested that the Bai ethnic group belonged to the southern group of Chinese.

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Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies

Mack²,

et al. 2008

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This paper presents a meta-analysis of high-resolution human leukocyte antigen (HLA) allele frequency data describing 497 population samples. Most of the datasets were compiled from studies published in eight journals from 1990 to 2007; additional datasets came from the International Histocompatibility Workshops and from the AlleleFrequencies.net database. In all, these data represent approximately 66,800 individuals from throughout the world, providing an opportunity to observe trends that may not have been evident at the time the data were originally analyzed, especially with regard to the relative importance of balancing selection among the HLA loci. Population genetic measures of allele frequency distributions were summarized across populations by locus and geographic region. A role for balancing selection maintaining much of HLA variation was confirmed. Further, the breadth of this meta-analysis allowed the ranking of the HLA loci, with DQA1 and HLA-C showing strongest balancing selection and DPB1 being compatible with neutrality. Comparisons of the allelic spectra reported by studies since 1990 suggest that most of the HLA alleles identified since 2000 are very-low-frequency alleles. The literature-based allele-count data, as well as maps summarizing the geographic distributions for each allele, are available online.

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Sequencing‐based analysis of the HLA‐DPB1 polymorphism in Nu ethnic group of south‐west China

Cited by 5 publications

References 31 publications

HLA‐DPB1 polymorphism in Blang and Puyi ethnic groups of Southwest China inferred from sequence‐based typing

HLA‐DPB1 polymorphism in Blang and Puyi ethnic groups of Southwest China inferred from sequence‐based typing

Polymorphism of HLA‐DRB1, ‐DQB1 and ‐DPB1 genes in Bai ethnic group in southwestern China

Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies

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