Sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following intensified, accelerated CEE (cyclophosphamide, epirubicin, etoposide) chemotherapy in patients with solid tumors

Modeling Multi-drug Chemotherapy: Tailoring Treatment to Individuals

“…Because there are few data regarding how long hematopoietic stem cells spend in the quiescent state, two alternative values of 4 days (p"1/96 hr\) or 14 days (p"1/336 hr\) are modeled (Killmann, 1968;Lord, 1997;Papayannopoulou et al, 2000). The parameter f is estimated to be 0.4 based on a PI of 30% and an SPF of 12% (Danova et al, 1996). Because TAM and HER speci"cally target tumor cells, and because myelosuppression is not a major toxicity for either drug, it is assumed that these two drugs do not have cytostatic e!ects on the bone marrow.…”