Sequential Administrations of a Vascular-Disrupting Agent, High-Intensity Focused Ultrasound, and a Radioactively labeled Necrosis Avid Compound for Eradicating Solid Malignancies

Abstract

Radical treatment of malignant solid tumors should aim to be less traumatic, precise, and effective. OncoCiDia, as a noninvasive, sequential dual-targeting, small-molecule, broad spectrum anticancer theranostic approach, may fulfill these requirements of solid cancer (Onco) treatment with both tumoricidal (Ci) and diagnostic (Dia) effects. However, it is unlikely to cure patients with cancer, especially those with large and irregular tumors and with tumors residing in certain organs, such as the brain and pancreas, because of insufficient necrosis generation. To amplify ablative efficacy, this shortcoming could be overcome by combining high-intensity focused ultrasound (HIFU) with the use of a vascular-disrupting agent (VDA) and a radioactively labeled necrosis avid compound (NAC), such as 131I-Hypericin (131I-Hyp), which are the first and second targeting drugs used in OncoCiDia. This study proposes the combined use of OncoCiDia and HIFU (Onco-HIFU-CiDia) as a synergistic treatment for malignant tumors to achieve a curative multimodality and multidrug regimen for patients with solid cancers, in accordance with the current trend of cancer patient care.

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

“…For chemotherapy and immunotherapy, although new treatment targets and novel drugs are increasingly studied, challenges, such as the low targeting efficacy and intrinsic toxicity of these treatments, remain to be overcome (4). In addition to these four pillars of cancer therapy, more recent studies have focused on developing and improving non-invasive and more patient-friendly modalities with improved treatment efficacy and a lower incidence of side effects: Among these, high-intensity focused ultrasound (HIFU) is a promising approach (5)(6)(7).…”