Sequential analysis of hair mercury levels in relation to fish diet of an Amazonian population, Brazil

Dolbec, Julie; Mergler, Donna; Larribe, Fabrice; Roulet, M.; Lebel, Jean; Lucotte, Marc

doi:10.1016/s0048-9697(00)00835-4

Cited by 131 publications

(85 citation statements)

References 20 publications

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“…This probably reflects the fact that those born on the Tapajo´s have a longer tradition of eating fish and those that live directly on the Tapajo´s eat fish more frequently and consume bigger portions. In addition, environmental mercury levels around the villages, differences in methylation rates (Guimara˜es, 2001;Roulet et al, 2001;Miranda et al, 2004), or simply changes in the availability of the different fish species present in the various ecosystems can also contribute to intervillage differences (Dolbec et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…In the Amazon, water levels vary by 6 m up to 20 m between the high-and low-water seasons causing important seasonal changes in fish habitat and behavior (Goulding et al, 1996;Bastos et al, 2007) and thus in the availability of different fish species for the riverside populations (Lebel et al, 1997;Dolbec et al, 2001;Passos et al, 2001). The rain cycle and local conditions likewise affect seasonal fruit availability (Passos et al, 2001).…”

Section: Fish and Fruit Intakementioning

confidence: 99%

“…During the last decade, a large number of exposure assessments of fish-eating populations have been conducted in different countries of the Amazon (Barbosa et al, 1997;Lebel et al, 1997;Cordier et al, 1998;Dolbec et al, 2001;Santos et al, 2003;Passos et al, 2003a;Gonc¸alves and Gonc¸alves, 2004;Webb et al, 2004;Do´rea et al, 2005;Bastos et al, 2006;Pinheiro et al, 2006). However, little attention has been given to the importance of mercury intake in these populations, although a limited number of studies have tried to estimate the rates of mercury intake Henshel, 1996, 2000;Bidone et al, 1997;Hacon et al, 1997;Kehrig et al, 1998;Fre´ry et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Daily mercury intake in fish-eating populations in the Brazilian Amazon

Passos

Silva

Lemire

et al. 2007

J Expo Sci Environ Epidemiol

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113

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Although high levels of fish consumption and bioindicators of mercury exposure have been reported for traditional populations in the Amazon, little is known about their actual daily intake of Hg. Using an ecosystem approach, calculate daily mercury intake in adult fish-eaters, examine the relations between mercury intake and bioindicators of exposure and the factors that influence these relations. A cross-sectional dietary survey on fish and fruit consumption frequency was carried out with 256 persons from six villages of the Tapajo´s River. Fish portion per meal was determined. Mercury concentration was determined for 1123 local fish specimens. Daily mercury intake (mg/kg/day) was determined for men and women from each village using the average fish-mercury concentration for the fish caught in their fishing zone, the average quantity of fish per meal, fish-species frequency consumption and participants' body weight. Fish-mercury averaged 0.33 mg/g70.33. Daily mercury intake varied between 0 and 11.8 mg/kg/day (mean 0.92 mg/kg/day70.89) and varied by gender and village. Mean blood-and hair-mercury were 58.7736.1 mg/l and 17.9711.5 mg/g, respectively. There was a strong and positive relation between blood-mercury and daily mercury intake, with an inverse relation for fruit intake and schooling; significant variations were observed with immigrant status, and among villages. Hair-mercury was directly associated with daily mercury intake and inversely related to schooling and fruit consumption. Fruit consumption modified the relation between daily mercury intake and blood-mercury levels: for the same daily mercury intake, persons eating more fruit had lower blood-mercury concentrations (ANCOVA Interaction term: F ¼ 10.9, Po0.0001). The median difference of the ratio of blood-mercury to daily mercury intake between low and high fruit consumers was 26, representing a 26.3% reduction. These findings reveal high levels of daily mercury intake. Rigorous studies for developing risk-based reference doses in the Amazon should be undertaken to orient viable risk-management strategies to reduce exposure, while maintaining fish diet.

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Section: Discussionmentioning

confidence: 99%

Section: Fish and Fruit Intakementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Daily mercury intake in fish-eating populations in the Brazilian Amazon

Passos

Silva

Lemire

et al. 2007

J Expo Sci Environ Epidemiol

Self Cite

113

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show abstract

“…[32] Populations in the Amazon communities who rely on freshwater fish have median hair Hg levels range from 5 to 15 µg g −1 . [33][34][35][36][37] In contrast, mean hair Hg levels in populations with minimal fish consumption range from 0.1 to 1.0 µg g −1 , and mean blood Hg levels similarly range from 1.0 to 5.0 µg L −1 . [38][39][40][41] The recent results in a national health study in the United States found that geometric mean hair mercury was 0.20 µg g −1 in women (among frequent fish consumers, the geometric mean hair mercury level was three-fold higher, 0.38 v. 0.11 µg g −1 in non-consumers) and in children 0.12 µg g −1 (the geometric mean hair mercury levels were two-fold higher, 0.16 v. 0.08 µg g −1 in non-consumers).…”

Section: New Zealandmentioning

confidence: 96%

Methylmercury exposure and health effects in humans

Choi¹,

Grandjean

2008

Environ. Chem.

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Environmental context. Dietary intake of fish and other seafood products is the dominant source of human exposure to methylmercury, a toxicant that can have serious adverse effects on the developing nervous system and may promote heart diseases. The existing evidence of human toxicity should inspire prudent choices in maintaining fish intakes to secure an ample supply of essential nutrients, while at the same time choosing species that are low in mercury concentrations. The combination of essential nutrients and avoidance of this toxic contaminant will benefit brain development and human health in general. In addition, current contamination levels suggest that intensified efforts are needed to reduce and eliminate mercury release to the environment.Abstract. Methylmercury (MeHg) is a worldwide contaminant found in seafood and freshwater fish, which constitute the dominant source of human exposure to this substance. The developing human brain is particularly susceptible to injury caused by MeHg, which easily passes the placental barrier. Epidemiological studies in fishing populations have found subtle though lasting adverse effects on brain functions of children who were exposed prenatally to MeHg from seafood diets. This contaminant also seems capable of promoting the development of heart disease. Fish and seafood also contain important nutrients, such as omega-3 fatty acids that may provide beneficial effects, thereby possibly counteracting or obscuring the adverse effects of MeHg. This article reviews the existing evidence on MeHg developmental neurotoxicity and the emerging evidence that MeHg may promote the development of heart diseases. MeHg risks may have been underestimated in the past, in part because of the confounding effects of nutrients from seafood and fish. Improved control of mercury release to the environment is indicated. In addition, regulatory agencies should provide better guidance to consumers in maintaining a balanced diet that includes seafood as low as possible in mercury.

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“…Recentemente foi publicado um estudo que ressalta a importância de considerar o Se nas análises de Risco à exposição de Hg em humanos (Zhang et al, 2014 (Boischio e Barbosa, 1993;Barbosa et al, 1997;Boischio e Cernichiari, 1998;De Oliveira et al, 2000;Dolbec et al, 2001;Bastos et al, 2006;Barbieri e Gardon, 2009;Berzas Nevado et al, 2010), porém, apenas alguns estudos indicaram efeitos neurológicos concretos nas populações estudadas, as quais apresentaram níveis mais baixos de Hg em cabelo do que os descritos nos casos de Minamata e Iraque (Lebel et al, 1998;Dolbec et al, 2000;Mergler et al, 2007).…”

Section: Selêniounclassified

Interações Mercúrio-Selênio: Uma Abordagem Integrada De Avaliação De Exposição Ao Mercúrio Em Populações Ribeirinhas No Município De Porto Velho, Rondônia

RUIZ¹

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AgradecimentosAgradeço a Deus e a todas as pessoas que fizeram possível eu estar aqui presente, concluindo meu doutorado.Meus pais e minha família salvadorenha por seu apoio incondicional e sempre acreditar em mim.Ao Prof. Reinaldo Calixto, que abriu as portas e aceitou me orientar, uma veterinária na área da química. À Profa. Sandra Hacon, que sempre me apoiou em todos os momentos, e incentivo na pesquisa e, além do mais, um exemplo de pesquisadora que me ensinou que o conhecimento tem que ser aplicado para melhorar uma realidade.Ao Prof. José Marcus Godoy que me aceitou como aluna em um momento difícil e me apoiou no desenvolvimento de minha pesquisa.Ao Rodrigo Araújo Gonçalves que sentou horas comigo para descobrir outros caminhos para contornar os obstáculos encontrados durante a pesquisa, e me ensinou a prática do método analítico. À equipe do "LAATOM" e da FIOCRUZ pelo apoio, amizade e paciência durante todo esse tempo. À família Brandão, minha família brasileira, pelo apoio incondicional e por ter me adotado e feito me sentir como parte da família.A todos os meus amigos brasileiros e salvadorenhos e de outras partes do mundo que estiveram comigo, física, virtualmente e em pensamento, me apoiando e animando nos momentos difíceis, e que sem sua companhia teria sido difícil superar.Um agradecimento especial a Teresa Durão, que se ofereceu para uma missão difícil, corrigir o Português da minha tese! Para Douglas Oliveira por ajudar nesses últimos detalhes e Fatima Almeida pela paciência e ajuda com esses tramites burocráticos.À CAPES pelo apoio financeiro, e à PUC-Rio pela bolsa de Isenção. O mercúrio na Amazônia brasileira tem sido estudado devido à ocorrência de garimpo de ouro, que é uma atividade que aumenta a carga do mercúrio neste ecossistema. A forma mais tóxica deste elemento é o metil mercúrio, que é um potente neurotóxico com propriedade de atravessar a barreira placentária e afetar o desenvolvimento do feto com consequências irreversíveis para o recém-nascido.As populações ribeirinhas da Região Amazônica têm como principal fonte de proteína a ingestão de peixe, que dependendo do seu nível trófico podem constituir uma importante fonte de metil-mercúrio para estas populações. Embora atividades como o garimpo tenham diminuído nos últimos anos, os projetos de desenvolvimento, na região Amazônica, podem aumentar os níveis de Hg incorporados na cadeia trófica em forma de metil mercúrio. O presente trabalho tem como objetivo avaliar a exposição de Hg (matriz sangue e cabelo), na etapa de pré-enchimento do reservatório de uma hidrelétrica no rio Madeira, com foco principal na saúde infantil, em duas comunidades ribeirinhas, localizadas nas áreas de influência direta e indireta da usina hidrelétrica. A avalição da exposição ao mercúrio foi analisada junto a outras variáveis importantes, como as concentrações de Se no sangue, dieta, parâmetros bioquímicos, antropométricos e pressão arterial, com o intuito de gerar uma informação baseline para comparações futuras dos padrões de exposição após do estabelecime...

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Sequential analysis of hair mercury levels in relation to fish diet of an Amazonian population, Brazil

Cited by 131 publications

References 20 publications

Daily mercury intake in fish-eating populations in the Brazilian Amazon

Daily mercury intake in fish-eating populations in the Brazilian Amazon

Methylmercury exposure and health effects in humans

Interações Mercúrio-Selênio: Uma Abordagem Integrada De Avaliação De Exposição Ao Mercúrio Em Populações Ribeirinhas No Município De Porto Velho, Rondônia

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