Sequential analysis of infarcted and normal myocardium in piglets using in vivo gadolinium-enhanced MR images

Dijkman, Paul R. M. van; Höld, Karin M.; Laarse, Arnoud van der; Holman, Eduard R.; Özdemir, Hüseyin; Nat, Tineke H. van der; Roos, Albert de; Wall, Ernst E. van der

doi:10.1016/0730-725x(93)90025-9

Cited by 20 publications

(8 citation statements)

References 25 publications

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“…This is in accordance with a histological study in a canine model by Reimer and colleagues, 15 who described a decrease of infarct size in the subacute phase by a factor of 4. In a porcine study, however, van Dijkman and colleagues 16 found little change in contrast enhancement between one and three weeks after coronary occlusion. According to their medical records, none of our patients had an acute myocardial infarction within two months before the first or in between the two MRIs.…”

Section: Discussionmentioning

confidence: 89%

Cardiac magnetic resonance imaging: long term reproducibility of the late enhancement signal in patients with chronic coronary artery disease

Bülow

2005

Heart

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Objective: To determine long term reproducibility of the late enhancement (LE) signal in contrast enhanced magnetic resonance imaging (MRI) and potential changes of the signal after revascularisation. Methods: 33 patients (29 men, mean (SD) 61 (11) years) with coronary artery disease (CAD) and left ventricular dysfunction (ejection fraction 30 (7)%) underwent two contrast enhanced MRI procedures within 9 (3) months. Fifteen patients (group A: 14 men, 59 (12) years) had no interventions between the two studies. Eighteen patients underwent revascularisation after MRI 1 (group B: 15 men, 62 (9) years). Changes in the LE signal between the first and second MRIs were investigated in both groups as well as intraobserver and interobserver variabilities for delineation of the signal. Results: The LE signal was highly reproducible in groups A and B for segmental analysis (concordance 86% v 82%, respectively; k = 0.70 v 0.67) and summed scores (group A: r = 0.97, p , 0.001; group B: r = 0.93, p , 0.001). The LE signal was quantified as 27 (27) , respectively, for the second MRI (both not significant). Moreover, low intraobserver and interobserver variabilities were observed in segmental analysis (k = 0.86 and 0.74, respectively, for group A, and k = 0.87 and 0.82, respectively, for group B). Conclusion: In patients with chronic CAD, the LE signal in contrast enhanced MRI is very stable over an extended time period. These results further characterise contrast enhanced MRI as a useful tool for myocardial viability assessment. Low intraobserver and interobserver variabilities promise robustness of the method for clinical application.

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Section: Discussionmentioning

confidence: 89%

Cardiac magnetic resonance imaging: long term reproducibility of the late enhancement signal in patients with chronic coronary artery disease

Bülow

2005

Heart

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“…The end systolic volume was derived from summation of all slices from the phase with the smallest endocar-235 dial volume. Left ventricular mass was defined by the difference of the epicardial volume and the endocardial volume, multiplied by the known density of the myocardium (1.05 g/cm 3) [21].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Reproducibility of left ventricular size, shape and mass with echocardiography, magnetic resonance imaging and radionuclide angiography in patients with anterior wall infarction

et al. 1996

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After myocardial infarction, left ventricular volume and ejection fraction can be assessed by echocardiography, magnetic resonance imaging and radionuclide angiography to guide therapy and determine prognosis. Whether a measured parameter gives the same results irrespective of the method used and the observer who performs the analysis is only partly known. Intra-observer and inter-observer variability were determined for echo and magnetic resonance imaging. Left ventricular ejection fraction measured by these techniques was related to radionuclide angiograms performed in the same period. Intra-observer variability for both echo and MRI was low and in most instances below 5%. Inter-observer variability for the echo and MRI measurements were substantially higher than intra-observer variability. Comparison of the three imaging modalities revealed systematic differences. Therefore, in clinical studies, left ventricular volume and function parameters have to be measured with the same technique and by the same observer in qualified core laboratories.

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“…Therefore, delayed enhancement MR imaging is the method of choice for the evaluation of myocardial viability. This method provides a good correlation with histopathological assessment of myocardial infarction [17,18]. As an improvement of myocardial function by revascularization is mainly achieved in patients with a transmural extent of less than 25% of the total wall thickness, exact depiction of the extent of myocardial infarctions is warranted for therapeutic decision making and patient prognosis [19,20].…”

Section: Introductionmentioning

confidence: 99%

Intraindividual comparison of myocardial delayed enhancement MR imaging using gadobenate dimeglumine at 1.5 T and 3 T

Klumpp

Sandstede²,

Lodemann

et al. 2008

Eur Radiol

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For contrast-enhanced imaging techniques relying on strong T1 weighting, 3 T provides increased contrast compared with 1.5 T. The aim of our study was the intraindividual comparison of delayed enhancement MR imaging at 1.5 T and at 3 T. Twenty patients with myocardial infarction were examined at 1.5 T and 3 T. Fifteen minutes after injection of contrast agent (0.1 mmol gadobenate dimeglumine per kg body weight), inversion recovery gradient recalled echo (IR-GRE) sequences were acquired (1.5 T/3 T: TR 11.0/9.9 ms, TE 4.4/4.9 ms, flip 30 degrees /30 degrees , slice thickness 6/6 mm) to assess myocardial viability. Two observers rated image quality (Wilcoxon signed rank test). Quantification of hyperenhanced myocardium and standardized SNR/CNR measurements were performed (Student's t test). There was no significant difference with respect to image quality (1.5 T/3 T: 3.5/3.3, p = 0.34, reader 1; 2.4/2.7, p = 0.12, reader 2) and infarction size (760 +/- 566/828 +/- 677 mm(2) at 1.5 T, 808 +/- 639/826 +/- 726 mm(2) at 3 T, reader 1/reader 2, p > 0.05). Mean SNR in hyperenhanced/normal myocardium was 19.2/6.2 at 1.5 T and 29.5/8.8 at 3 T (p < 0.05). Mean CNR was 14.3 at 1.5 T and 26.0 at 3 T (p < 0.05). Delayed enhancement MR imaging at 3 T is a robust procedure yielding superior tissue contrast at 3 T compared with 1.5 T which is, however, not reflected by increased image quality.

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Sequential analysis of infarcted and normal myocardium in piglets using in vivo gadolinium-enhanced MR images

Cited by 20 publications

References 25 publications

Cardiac magnetic resonance imaging: long term reproducibility of the late enhancement signal in patients with chronic coronary artery disease

Cardiac magnetic resonance imaging: long term reproducibility of the late enhancement signal in patients with chronic coronary artery disease

Reproducibility of left ventricular size, shape and mass with echocardiography, magnetic resonance imaging and radionuclide angiography in patients with anterior wall infarction

Intraindividual comparison of myocardial delayed enhancement MR imaging using gadobenate dimeglumine at 1.5 T and 3 T

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