Sequential changes in lung injury induced by preformed immune complexes

The Role of Complement-Derived Chemotactic Factors in Lung Injury Induced by Preformed Immune Complexes

“…In addition, reduced activity of chemotactic factors resulted in a marked reduction of accumulation of neutrophils in bron choalveolar lavage fluids, indicating that chemotactic fac tors play an important role in the sequestration of neutro phils on the alveolar side of the lung. The current observa tions are consistent with previous studies which have shown that the enhanced activity of chemotactic factors in bronchoalveolar lavage fluids preceded an increase in the PMNs in the lavage fluids [7]. However, other mediators of chemotactic factors for PMNs as well as complementderived chemotactic factors arc responsible for lung injury produced by preformed immune complexes, since com plement depletion did not completely abrogate the pul monary inflammation.…”

Delay of LPS-Induced Acute Lung Injury Resolution by Soluble Immune Complexes Is Neutrophil Dependent

“…LPS-induced MIP-2 in BALF, on the other hand, can allure more neutrophils to the infected lung (increased cellular exudation in Table 2) and lead to tissue inflammation. Immune complexes alone have previously been used to trigger ALI in naive rats by Scherzer and Ward (27) and Yoshizawa et al (28). They have reported that it is the PICX precipitating in lung tissues that leads to ALI.…”