Sequential changes in plasma selenium concentration after cadaveric renal transplantation

Abstract

Low plasma selenium concentrations are common at the time of transplantation but appear to normalize thereafter. The identification of low selenium levels in patients who experience CAR or CMV (two important risk factors for clinically apparent CGN) suggests that the relationship between selenium and CGN warrants further investigation.

Assessment of Oxidative Stress in the Early Posttransplant Period: Comparison of Cyclosporine A and Tacrolimus-Based Regimens

“…In addition, these drugs seem to play an important role in endothelin-induced arterial hypertension, which may additionally contribute to the oxidant stress [33]. However, there are several reports arguing against the increased oxidative stress due to calcineurin-inhibiting drugs [9,10,11, 34, 35]. The discrepancies of the above reports may come out of the diverse properties of the study groups, methods and dosages of the drugs.…”

“…Also, statins and ACE inhibitors, which are widely used in CRF have antioxidant effects [24, 25]. Moreover, the presence of infections or chronic graft nephropathies may worsen the oxidative stress [10, 26]. The period of cold ischemic preservation can also cause generation of reactive oxygen species (ROS) and consequent tissue injury [27].…”

“…Both drugs are reported to enhance oxidative stress and augment atherosclerosis by increasing the oxidizability of low-density lipoprotein (LDL) particles [7, 8]. Yet the data are controversial as there are inconsistent reports indicating unaltered [9] or improved oxidative stress following kidney transplantation [10, 11]. The reasons of these inconsistencies possibly include; the diverse characteristics of the study populations, accompanying drugs taken by the patients, and conflicting methods used for the measurement of oxidative stress in post transplantation period.…”

“…The reasons of these inconsistencies possibly include; the diverse characteristics of the study populations, accompanying drugs taken by the patients, and conflicting methods used for the measurement of oxidative stress in post transplantation period. The effects of alternate regimes on oxidative stress are not well studied [9,10,11]. Some reports claim that different calcineurin inhibitors have different effects on oxidative stress.…”

Selenium (Se), Blood Glutathione Peroxidases and DNA Damage in Chronic Kidney Disease Patients on Hemodialysis and After Kidney Transplantation - The Effect of Se Supplementation

“…In the next two months there was a further, slight increase in Se concentration. Morris-Stiff et al (2005) have shown that in 30, out of 40 patients before transplantation Se level in plasma was lower than in healthy subjects, but this was normalized in the majority of patients within 3 months. A decrease of Se in the first few days after surgery in our study is very likely associated with the restricted protein intake (the main source of Se) just after surgery.…”