Sequential Changes in Reticuloendothelial System Function After Acute Hemorrhage

Altura, Burton M.; Hershey, S. G.

doi:10.3181/00379727-139-36270

Cited by 37 publications

(11 citation statements)

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“…Gastrointestinal hemorrhage has been shown to impair the reticuloendothelial function and facilitate bacterial translocation across the gut. 32,33 Likewise, the association of renal failure with infections is well recognized.…”

Section: Discussionmentioning

confidence: 99%

Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality

et al. 1998

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Determinants of outcome and the utility of the Child-Pugh score and the acute physiology and chronic health evaluation (APACHE) II score as predictors of outcome were prospectively assessed in 54 consecutive patients with cirrhosis requiring intensive care unit (ICU) management. Overall mortality in the ICU was 43% (23/54). Child-Pugh scores did not differ between survivors or nonsurvivors (12.8 versus 12.3, P = 0.26), however APACHE II scores (P = 0.007), acute physiology scores (P = 0.006), and Karnofsky scores (P = 0.001) were significant predictors of outcome. By univariate analysis, requirement of mechanical ventilation analysis (P = 0.001), duration of mechanical ventilation (P = 0.001), pulmonary infiltrates (P = 0.0001), infections (P = 0.047), gastrointestinal bleeding (P = 0.005), and serum creatinine >1.5mg/dl (P = 0.0005) were significantly associated with mortality. By logistic regression analysis only pulmonary infiltrates (P = 0.0001) and renal dysfunction (P = 0.041) were independent predictors of mortality. When controlled for the severity of illness (APACHE II scores), the mortality in patients with cirrhosis caused by alcohol was significantly lower than that in patients with liver disease not caused by alcohol (P = 0.01). Our study not only identified predictors of poor outcome in patients with cirrhosis requiring ICU care but also provided data that may have implications for optimal timing for transplantation.

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Section: Discussionmentioning

confidence: 99%

Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality

et al. 1998

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“…Several investigators have demonstrated that HS results in depression of migration and phagocytic capacity of neutrophils and reduced phagocytosis and killing of cells within the reticuloendothelial system (11)(12)(13)47), as well as depression of cellular immunity, notably splenocyte functions (14 -18). We examined the livers of mice 24 hrs after intraperitoneal inoculation, using myeloperoxidase staining to evaluate whether there were differences in intrahepatic sequestration of leukocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Dysfunction of both the innate and acquired arms of the immune response may occur following HS and may contribute to the increased susceptibility to infections. Several investigators have demonstrated depression of the phagocytic capacity of the reticuloendothelial system and impaired intracellular killing following acute hemorrhage (11,12). More recently, in baboons, neutrophil migratory activity has been shown to be greatly decreased shortly after onset of HS (13).…”

mentioning

confidence: 99%

Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock*

Arıkan

Mastrangèlo

et al. 2006

Critical Care Medicine

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“…The effects of trauma on in vivo RES function have been studied extensively in animal models. For example, it has been shown that insults as diverse as hemorrhage (2,3,63), Noble-Collip drum trauma (22), burns (44), limb ischemia (48), and surgery (38) decrease phagocytic clearance rate. Studies by Kaplan and Saba have shown that the phagocytic clearance rate is depressed soon after nonlethal trauma, returning to normal after 6 to 24 h, whereafter stimulated phagocytosis occurs (22,36).…”

Section: Discussionmentioning

confidence: 99%

Effects of Colloidal Resuscitation Fluids on Reticuloendothelial Function and Resistance to Infection after Hemorrhage

Rijen

Ward

Little

1998

Clin Diagn Lab Immunol

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The effects of three resuscitation fluids, hydroxyethyl starch (HES), Haemaccel, and fresh autologous blood, on reticuloendothelial system phagocytic and catabolic functions and resistance to infection after 40% hemorrhages in BALB/c mice were studied. The mice, anesthetized with isoflurane, were bled over a 10-min period, left hypovolemic for 30 min, and then resuscitated with their shed blood or the same volume of asanguineous fluid. Normothermia was maintained throughout the experiments. The uptake and catabolism of intravenously injected double-labelled sheep erythrocytes (51Cr-125I-SRBC) in liver and spleen were determined at 1 and 48 h after hemorrhage. No significant changes in the uptake or catabolism of SRBC in liver or spleen were found at 1 h after hemorrhage and resuscitation with any of the fluids. However, at 48 h a significant increase in liver uptake of SRBC was seen in animals resuscitated with either Haemaccel or HES compared to that in animals resuscitated with shed blood or in animals subjected to a sham operation. The increase in liver uptake was accompanied by a small decrease in spleen uptake in animals resuscitated with Haemaccel but not with HES. No great changes in catabolic activity were seen at 48 h, although activity levels tended to be higher in animals resuscitated with Haemaccel. Separate groups of animals were challenged by an intraperitoneal injection with live Escherichia coliat 1 or 48 h after hemorrhage and resuscitation. Sixty-four percent of the animals resuscitated with shed blood survived the challenge with E. coli at 1 h after hemorrhage, whereas only 10 and 0% survival was seen for animals resuscitated with Haemaccel and HES, respectively. At 48 h survival was 80% for shed-blood-resuscitated animals and 60 and 70% for Haemaccel- and HES-resuscitated animals, respectively.

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Sequential Changes in Reticuloendothelial System Function After Acute Hemorrhage

Cited by 37 publications

References 0 publications

Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality

Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality

Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock*

Effects of Colloidal Resuscitation Fluids on Reticuloendothelial Function and Resistance to Infection after Hemorrhage

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