Sequential classification of endocrine stages during reproductive aging in women: the FREEDOM study*

Miró, F.; Parker, S. W.; Aspinall, L.; Coley, John; Perry, Paul; Ellis, Jayne E.

doi:10.1097/01.gme.0000147018.30796.25

Cited by 38 publications

(28 citation statements)

References 39 publications

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“…While the majority of women experience menopause between the ages of 45 and 55 years, approximately 5% of women will enter menopause early, between the ages of 40 and 45 years. 7, 8 Menopause occurring before the age of 40 years is described as premature and occurs in approximately 1% of women. 9 This early loss of ovarian function may relate to a number of etiologies, including genetic disorders, autoimmune disorders, infections, or iatrogenic causes related to chemotherapy, radiation, or surgery.…”

Section: Introductionmentioning

confidence: 99%

Long-term health consequences of premature or early menopause and considerations for management

et al. 2015

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Aim To review the current evidence concerning the long-term harmful effects of premature or early menopause, and to discuss some of the clinical implications. Material and methods Narrative review of the literature. Results Women undergoing premature or early menopause, either following bilateral salpingo-oophorectomy or because of primary ovarian insufficiency, experience the early loss of estrogen and other ovarian hormones. The long-term consequences of premature or early menopause include adverse effects on cognition, mood, cardiovascular, bone, and sexual health, as well as an increased risk of early mortality. The use of hormone therapy has been shown to lessen some, although not all of these risks. Therefore, multiple medical societies recommend providing hormone therapy at least until the natural age of menopause. It is important to individualize hormone therapy for women with early estrogen deficiency, and higher dosages may be needed to approximate physiological concentrations found in premenopausal women. It is also important to address the psychological impact of early menopause and to review the options for fertility and the potential need for contraception, if the ovaries are intact. Conclusions Women who undergo premature or early menopause should receive individualized hormone therapy and counseling.

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Section: Introductionmentioning

confidence: 99%

Long-term health consequences of premature or early menopause and considerations for management

et al. 2015

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“…With the advancement of technology, other reliable, objective and less user-dependent methods have been introduced, which rely on the analysis of the levels of reproductive hormones measured in urine [26]. The study of hormonal profiles in urine during the menstrual cycle has proved to be very valuable in understanding menstrual cycle dynamics, as well as variability in ovulation [19,27,28]. Likewise, urinary hormone testing has become an established application for personal monitoring of fertility awareness [9].…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal analysis of urinary LH and PdG was conducted using AutoDELFIA (Perkin Elmer, Waltham, USA) as previously described [19]. The in-house LH assay consists of immobilised biotinylated antibody (antibody #2119; SPD Development Co., Ltd, Bedford, UK) that recognises the alpha LH subunit bound to streptavidin plates, and a second, europium-labelled antibody that recognises the beta subunit (antibody #2301; SPD Development Co., Ltd, Bedford, UK), thus it is only able to measure intact LH.…”

Section: Sample Analysismentioning

confidence: 99%

Comparison between the different methods developed for determining the onset of the LH surge in urine during the human menstrual cycle

Godbert¹,

Miró²,

Shreeves³

et al. 2015

Arch Gynecol Obstet

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Purpose To determine whether an optimal method exists for the detection of the luteinising hormone (LH) surge onset in research datasets of urinary hormonal profiles of menstrual cycles. Methods The scientific literature was searched to compare published methodologies for detection of the LH surge onset in urine. Their performance was tested using complete hormonal profiles from 254 ovulatory cycles from 227 women attempting pregnancy (normal regular menstrual cycles; no known infertility). Results Three major methodologies to determine the onset of the LH surge in urine were identified. The key difference between these methods is how the cycle days that contribute to LH baseline assessment are determined: using fixed days (method #1), based on peak LH day (method #2), based on a provisional estimate of the LH surge (method #3). Method #1 requires no prior cycle information, whereas methods #2 and #3 need to consider complete cycle data. The most reliable method for calculation of baseline LH was using 2 days before the estimated surge day, plus the previous 4/5 days. Conclusions Different methods for identification of the urinary LH surge can provide very different determinations of LH surge day, thus care must be taken when comparing between studies that apply different methodologies. The optimal method for determining the onset of the LH surge in urine requires retrospective estimation of day of LH surge to identify the most appropriate part of the cycle to consider as the baseline. This method can be adopted for application in population studies.

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“…L'ovariectomie bilaté rale, é tape souvent indispensable de cette chirurgie, est associé e à l'installation brutale chez des patientes non mé nopausé es (ou à l'aggravation chez des patientes mé nopausé es) de symptômes lié s à une carence oestrogé nique tels que les bouffé es de chaleurs, la sé cheresse vaginale et la baisse de la libido [48].…”

Section: Prise En Charge Chirurgicaleunclassified

Étude de la qualité de vie dans les néoplasies ovariennes : outils et enjeux

Bryand

Hamidou

Paget‐Bailly

et al. 2015

Gynécologie Obstétrique & Fertilité

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Sequential classification of endocrine stages during reproductive aging in women: the FREEDOM study*

Abstract: This classification provides a detailed insight into the endocrinology of reproductive aging in women that could be useful for both clinical guidance and personal health care.

Cited by 38 publications

References 39 publications

Long-term health consequences of premature or early menopause and considerations for management

Long-term health consequences of premature or early menopause and considerations for management

Comparison between the different methods developed for determining the onset of the LH surge in urine during the human menstrual cycle

Étude de la qualité de vie dans les néoplasies ovariennes : outils et enjeux

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