Sequential Co-infection of Heligmosomoides polygyrus and Mycobacterium tuberculosis Determine Lung Macrophage Polarization and Histopathological Changes

Wulandari, Laksmi; Amin, Muhammad; Soedarto,; Soegiarto, Gatot; Ishiwata, Kenji

doi:10.1016/j.ijtb.2020.10.008

Cited by 1 publication

(1 citation statement)

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“…However, the existence of nematode infections tends to generate an acquired immune response, mainly mediated by type 2 T-Cells (Th2), downregulating Th1 response [13]. Furthermore, helminths infections stimulate the production of alternatively activated macrophages with poor phagocytic activity [14]. Consequently, a recent study has shown that the application of long-term deworming programs in wild boar may also reduce the severity of TB lesions in this species [13].…”

Section: Introductionmentioning

confidence: 99%

Combination with Annual Deworming Treatments Does Not Enhance the Effects of PCV2 Vaccination on the Development of TB in Wild Boar Populations

Galapero,

Ramos,

Benítez-Medina

et al. 2023

Animals

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Vaccination against PCV2 has been proven to be an effective measure to reduce the severity of TB in wild boar. The combination of this measure with strategies focused on treating other key concomitant pathogens, such as nematodes, could be a useful strategy. This study assesses whether a combination of deworming treatments and PCV2 vaccination may reduce the prevalence and severity of TB in wild boar. The study was conducted on five game estates in mid-western Spain where four groups of wild boar were produced: control, vaccinated, dewormed and vaccinated-dewormed. Wild boars from all groups were hunted between 2017 and 2020, and all of them received a TB diagnosis based on pathological and microbiological tests. Generalised linear models were used to explore the effect of deworming and PCV2 vaccination on TB prevalence and severity. PCV2-vaccinated animals showed lower probabilities of suffering severe TB lesions. However, no differences regarding TB severity were found between dewormed and non-dewormed wild boar. PCV2 vaccination reduces TB severity in wild boar. However, annual deworming does not produce a long-term parasitological reduction that can influence the development of TB in wild boar, nor does it improve the effect of PCV2 vaccination on TB.

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Section: Introductionmentioning

confidence: 99%