2020
DOI: 10.1016/j.biomaterials.2020.119907
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Sequential delivery of nanoformulated α-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer

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Cited by 75 publications
(44 citation statements)
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“…In view of the research work of Huang's research group, it is shown that genotoxic chemicals can cause DNA damage in CAFs, and thereafter induction of Wnt16 secretion can contribute to the drug resistance in neighboring cancer cells 253 . Many low-toxic natural anti-fibrotic compounds, such as quercetin, puerarin, α -mangostin 254 and fraxinellone 255 , have the ability to down-regulate the expression of WNT/ β -catenin in a variety of cell lines, thereby reversing tumor resistance to cytotoxic chemicals. Hu et al.…”
Section: Strategies To Enhance Nps Into Tumorsmentioning
confidence: 99%
“…In view of the research work of Huang's research group, it is shown that genotoxic chemicals can cause DNA damage in CAFs, and thereafter induction of Wnt16 secretion can contribute to the drug resistance in neighboring cancer cells 253 . Many low-toxic natural anti-fibrotic compounds, such as quercetin, puerarin, α -mangostin 254 and fraxinellone 255 , have the ability to down-regulate the expression of WNT/ β -catenin in a variety of cell lines, thereby reversing tumor resistance to cytotoxic chemicals. Hu et al.…”
Section: Strategies To Enhance Nps Into Tumorsmentioning
confidence: 99%
“…For example, silk fibroin nanoparticles loaded with triptolide and celastrol have a certain synergistic effect, which includes reducing cell viability and significantly increasing the cell apoptosis rate, and may be used in a promising treatment strategy for pancreatic cancer 44 . The latest research shows that triptolide can be loaded onto CRPPR peptide-modified tumor-targeting acid-triggered micelles, which can improve the therapeutic effect of triptolide and reduce damage to off-target organs 45 . Therefore, it is believed that nontoxic nanomedicines based on active substances in traditional Chinese herbs have great potential as targeted and adjuvant chemotherapy for pancreatic cancer.…”
Section: Biological Functionsmentioning
confidence: 99%
“…At present, the clinical dosage forms of traditional Chinese medicine mainly stay in the traditional dosage forms such as ointment, soup, pill and powder, while the anti-tumor active components contained in some traditional Chinese medicine show such drawbacks as poor water solubility, low bioavailability and low speci city distribution. Besides, most of them are administered orally, and the active, ineffective and even toxic components of the preparation are also introduced into the body [42]. With the drug encapsulated in the nano-drug delivery system, the active components of traditional Chinese medicine can penetrate the reticuloendothelial system, which not only improves the solubility of the drug, but also enhance the performance of the drug in tumor targeting through passive and active targeting.…”
Section: Effect Of Ccm@msns-isoim On the Survival Rate Of Oci-ly10 Cementioning
confidence: 99%