Unmanned aerial systems (UASs) find diverse applications across military, civilian, and commercial sectors, including military reconnaissance, aerial photography, environmental monitoring, precision agriculture, logistics, and rescue operations, offering efficient, safe, and cost-effective solutions to various industries. To ensure the stable and reliable operation of UASs, fault diagnosis is essential, which can enhance safety, and minimize potential risks and losses. However, most existing fault diagnosis methods rely on a single physical quantity as the primary information source or solely consider fault data at a single moment, leading to challenges of low diagnostic accuracy and limited reliability. Aimed at this problem, this paper presents a fault diagnosis method based on time–space domain weighted information fusion for UASs. First, the Gaussian fault model is constructed for the data with different fault features in the space domain. Next, the weighted coefficient method is used to generate the basic probability assignment (BPA) by matching the fault data with the Gaussian fault model. Then, the Dempster’s combination rule, which enables the Dempster–Shafer (D-S) evidence theory, is adopted to fuse the generated BPAs. Based on this, the pignistic probability transformation is performed to determine the fault type. Finally, numerical results demonstrate the effectiveness of the proposed fault diagnosis method in accurately identifying the fault types of UASs.