Sequential intravenous-oral amoxycillin/clavulanate (Augmentin) therapy in paediatric hospital practice

Oral versus intravenous antibiotics in treatment of paediatric febrile neutropenia

“…Only sequential IV then oral antibiotics Klastersky 50 A review Klastersky et al 51 A review; adult population only Koh and Pizzo 52 A review Kridel et al 53 A review Lau et al 54 Prospective, not randomised clinical trial; adult population only; sequential IV-oral antibiotics for the treatment of patients with fever and neutropenia Leverger 55 A review Marra et al 56 Prospective, not randomised clinical trial; step down dosage of IV ciprofloxacin, then switch to oral when criteria were met Minotti et al 21 Included neutropenic and non-neutropenic patients without discrimination Mullen 57 A review Niho et al 14 Adult population only Paganini et al 58 Sequential IV to oral treatment was given to both arms Park et al 59 Not randomised as oral vs. intravenous concurrently. Only sequential IV then oral antibiotics Roguin et al 60 IV therapy only, no oral treatment arm Rubenstein et al 15 Adult population only Rubenstein and Rolston 61 A review Sahu et al 62 Combined oral and IV therapy; non-randomised prospective clinical trial Santos-Machado et al 63 Retrospective, non-randomised clinical trial Schaad et al 64 Patients were not immunocompromised or neutropenic Sebban et al 16 Adult population only Shenep 4 A review Shrestha et al 65 Prospective, not randomised clinical trial Timmers et al 66 Prophylactic antibiotics Vidal et al 17 Meta-analysis; adult and paediatric populations combined Wacker et al 67 Prospective, not randomised clinical trial IV, intravenous. reported cases of vomiting in the included trials.…”