Sequential liver transplantation

Ten Years of Experience with Liver Transplantation for Familial Amyloid Polyneuropathy in Japan: Outcomes of Living Donor Liver Transplantations

“…Liver tissue explanted from FAP patients has normal structure and function except for the production of amyloidogenic variant TTR, and domino liver transplantation using FAP liver grafts has been employed to compensate for the shortage of available liver grafts (7)(8)(9). In other countries, 70% of these operations were performed in patients with liver tumors, and 30% for non-malignant conditions (7).…”

“…Since then, more than 800 patients in 16 countries have undergone orthotopic liver transplantation (OLT) (7). Moreover, domino (sequential) liver transplantation using a graft from the FAP patient was first performed in Portugal (8) in 1995, and more than 200 domino transplant procedures reutilizing explanted FAP livers had been performed by the end of 2002 (7,9).…”

Domino liver transplant: influence on the number of donors and transplant coordination

“…In 1995 a new transplant technique-sequential transplant or domino liver transplant (DLT) 1 was developed in Portugal, by a team led by Prof Linhares Furtado (Coimbra University Hospital); called implantation of a full-size liver from a patient with familial amyloidosis polyneuropathy (FAP), type I into a subject accompanied by transplantation of a cadaveric liver to the donor.…”

The Coimbra University Hospital experience in liver transplantation in patients with familial amyloidotic polyneuropathy

“…Usually the disease becomes clinically apparent in the third decade of life, especially for the Portuguese variety, and progresses to death in 10 to 14 years. [1][2][3][4][5] Today liver transplantation is the only successful treatment for the disease. 4 -6 Furthermore, the livers from patients with FAP can be used with success for other patients awaiting a liver transplant, such as patients with liver tumors and/or cirrhosis.…”