Sequential Microwave-Ultrasound-Assisted Extraction for Isolation of Piperine from Black Pepper (Piper nigrum L.)

Gorgani, Leila; Mohammadi, Maedeh; Najafpour, Ghasem; Nikzad, Maryam

doi:10.1007/s11947-017-1994-0

Cited by 68 publications

(46 citation statements)

References 33 publications

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“…The time required for PPN extraction has been reported as 12 h for DBSA extraction (Subramanian et al, ); 2–5 h for SFE and 2 h for hydrotropic solubilization (SFE; Dutta & Bhattacharjee, ); 2.5 h for enzyme‐assisted SFE; and 135 min for SC‐CO 2 extraction (Dutta & Bhattacharjee, ). In addition, these methods require a high solvent volume: 300 mL for Soxhlet extraction (Gorgani et al, ); 50–100 mL for ultrasound‐assisted extraction and batch solvent extraction (Rathod & Rathod, ); and 150 mL for SC‐CO 2 (Solati, Baharin, & Bagheri, ). In this work, the ASE method was applied as a fast and reliable method for extraction of PPN from BP samples.…”

Section: Discussionmentioning

confidence: 99%

“…Another major driving factor influencing the use of these three samples in the Bhattacharjee, 2017). In addition, these methods require a high solvent volume: 300 mL for Soxhlet extraction (Gorgani et al, 2017); 50-100 mL for ultrasound-assisted extraction and batch solvent extraction (Rathod & Rathod, 2014); and 150 mL for SC-CO 2 (Solati, Baharin, & Bagheri, 2014). In this work, the ASE method was applied as a fast and reliable method for extraction of PPN from BP samples.…”

Section: Discussionmentioning

confidence: 99%

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Quality variation and standardization of black pepper (Piper nigrum): A comparative geographical evaluation based on instrumental and metabolomics analysis

Ahmad

Amir

Aljishi

et al. 2020

Biomedical Chromatography

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Black pepper (Piper nigrum; BP), known as the ‘king of spices’, imported from various countries is widely available in Saudi Arabian markets, as its demand as a food as well as a medicine for minor ailments is increasing in the country. However, there is a lack of appropriate information regarding these samples in terms of quality variation and standardization. We thus aimed to evaluate the quality and standardize the BP sample with respect to its physicochemical characters, active principle variation [i.e. piperine (PPN)], toxicity, and biological activity. The main focus is to validate whether any difference exists in the quality and quantity of active principle in these samples. For this purpose, physicochemical (chemical tests and ash values) and instrumental analyses [accelerated solvent extraction (ASE), ultra‐high‐pressure liquid chromatography (UHPLC)‐diode array detector, infrared (IR), nuclear magnetic resonance (NMR), and inductively coupled plasma‐MS (ICP‐MS)] and biological evaluation {in vitro antioxidant activity [2,2‐diphenyl‐1‐picrylhydrazyl and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid)] and cytotoxicity assay} were performed. An extract yield (g) with %recovery of 2.26 ± 4.24 (11.3) was obtained for the Vietnamese sample, using a fast and rapid method of extraction (ASE). These values were 1.22 ± 2.64 (6.1) and 0.75 ± 1.69 (3.75) for the Pakistani and Indian samples. Physicochemical tests revealed the presence of flavonoids and phenolic compounds in all samples; however, in the Vietnamese sample a low amount of total, acid‐insoluble, and high water‐soluble ash value was noted. IR and NMR was applied to further standardize the samples. Results of ICP‐MS analysis showed a high amount of macronutrients and micronutrients in the samples tested while UHPLC analysis revealed a high amount of PPN (ng/mL) in the Pakistani sample (1,362,614.09); these values were 1,051,848.04 and 768,512.81 for the Vietnamese and Indian samples, respectively. In vitro antioxidant and cytotoxicity activities revealed higher potential for the Vietnamese sample. The samples were properly standardized and effectively differentiated in terms of quality and biological activities using a fast and reliable method, however it certainly does not mean that a particular geographical region is more better or productive in terms of herbal products.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quality variation and standardization of black pepper (Piper nigrum): A comparative geographical evaluation based on instrumental and metabolomics analysis

Ahmad

Amir

Aljishi

et al. 2020

Biomedical Chromatography

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“…During the experiments, beaker was rotated to ensure an equal distribution of heat in samples. Since extensive heating causes the solvent to pour outside the beaker and for avoiding any solvent waste, heating was intermittent [20,29]. At the end of each run and before conducting the HPLC tests, samples were taken out of the microwave and filtered.…”

Section: Microwave-assisted Extraction Of Quercetinmentioning

confidence: 99%

“…Use of domestic microwave oven for laboratory work was first started by Samra in 1975 for analysis biological samples [18]. Since then, various experiments have been conducted by utilizing microwave radiation as a method of extraction of organic compounds [19,20]. Nonionized electromagnetic microwaves, which are located in the mid-range of infrared and x-rays electromagnetic spectrum, have frequencies between 300 MHz to 300 GHz.…”

Section: Introductionmentioning

confidence: 99%

“…Various studies [20,[22][23][24][25][26] have been carried out for comparing efficiency of microwave assisted extraction (MAE) with traditional techniques, such as solvent maceration and Soxhlet. They observed that large amounts of solvent and longer times are required for traditional methods, while MAE techniques result in more material in less time.…”

Section: Introductionmentioning

confidence: 99%

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Sequential Microwave-assisted Extraction for Isolation of Quercetin from Red Kidney Bean

Aghajanian

Kazemi

Esmaeili

et al. 2020

IJE

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Quercetin is a biological flavonoid, which can be found in red kidney bean at high concentration. In this study, a comparison was conducted between traditional and modern extraction methods. Sequential microwave-assisted extraction was used for isolation of quercetin from red kidney bean. The effect of several factors such as particle size of grinded kidney bean, extraction solvent, microwave power and extraction time on the extraction yield of quercetin was considered. To analyze the quercetin, HPLC method was developed. The highest extraction efficiency was obtained (35.8 mg quercetin /g kidney bean) when 60 w/w% acetone used as the solvent. In addition, the solvent to solid ratio was 10:1 and the irradiation power of 800W was applied for the experiment duration of 1 min. Acquired extraction yield according to the current method was higher than extracted quercetin from soxhlet (24.6 mg quercetin /g kidney bean) and maceration (32.75 mg quercetin /g kidney bean). In the present study, quercetin was successfully extracted from kidney bean by microwave-assisted extraction. Quercetin structure remains intact and can be used to produce therapeutic compounds.

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Exploring the potential of spice‐derived phytochemicals as alternative antimicrobial agents

Wong,

Chow

2023

eFood

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The emergence and spread of pathogenic bacterial resistance to many antibiotics are on the rise globally, thereby posing a significant threat to public health. In response, scientists are actively investigating alternative therapeutic agents to combat antibiotic‐resistant microorganisms. This review focuses on the antimicrobial effects of commonly consumed spices, namely garlic, chilli peppers, turmeric, ginger and black pepper, which have shown promising results in previous research. The review highlights the key phytochemicals, including allicin, ajoene, capsaicin, dihydrocapsaicin, curcumin, 6‐gingerol, 6‐shogaol and piperine, responsible for their antimicrobial activities. Various pharmacological experiments to elucidate the action mechanism and metabolism of those bioactive compounds are described. Moreover, the synergistic effects of these phytochemicals with conventional antibiotics are discussed, emphasizing the potential to reduce the required antibiotic dosage for effective microbial inhibition. The review also addresses the gaps in current research, such as the variations in antimicrobial assay results across different research groups and the incomplete understanding of the synergistic mechanisms between antibiotics and phytochemicals. Finally, future research directions and opportunities are suggested to further explore the antimicrobial potential of these spice‐derived phytochemicals and bridge the existing knowledge gaps.

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Sequential Microwave-Ultrasound-Assisted Extraction for Isolation of Piperine from Black Pepper (Piper nigrum L.)

Cited by 68 publications

References 33 publications

Quality variation and standardization of black pepper (Piper nigrum): A comparative geographical evaluation based on instrumental and metabolomics analysis

Quality variation and standardization of black pepper (Piper nigrum): A comparative geographical evaluation based on instrumental and metabolomics analysis

Sequential Microwave-assisted Extraction for Isolation of Quercetin from Red Kidney Bean

Exploring the potential of spice‐derived phytochemicals as alternative antimicrobial agents

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